HIV 感染者女童接种四价人乳头瘤病毒疫苗的免疫原性和安全性。
Immunogenicity and Safety of the Quadrivalent Human Papillomavirus Vaccine in Girls Living With HIV.
机构信息
From the Department of Pediatrics, Children's Hospital of Eastern Ontario, University of Ottawa, Ottawa, Ontario, Canada.
Department of Pediatrics, University of Toronto, Toronto, Ontario, Canada.
出版信息
Pediatr Infect Dis J. 2018 Jun;37(6):595-597. doi: 10.1097/INF.0000000000001874.
We evaluated quadrivalent human papillomavirus vaccine seroresponses among 35 girls living with HIV (9-13 years of ages) and compared with data on girls without HIV, as part of a subgroup analysis. The quadrivalent human papillomavirus vaccine was safe and well tolerated. However, antibody response was significantly lower in girls living with HIV relative to girls without HIV. HIV virologic suppression predicted better antibody response.
我们评估了 35 名感染 HIV 的女孩（9-13 岁）接种四价人乳头瘤病毒疫苗后的血清学反应，并与未感染 HIV 的女孩进行了比较，这是亚组分析的一部分。四价人乳头瘤病毒疫苗是安全且耐受良好的。然而，与未感染 HIV 的女孩相比，感染 HIV 的女孩的抗体反应明显较低。HIV 病毒学抑制情况预测了更好的抗体反应。
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