Zhang Zheng, Chen Guo-Chong, Qin Zhi-Zhen, Tong Xing, Li Da-Peng, Qin Li-Qiang
a Department of Nutrition and Food Hygiene , School of Public Health, Soochow University , Suzhou , Jiangsu Province , China.
b School of Public Health, Hebei Medical University , Shijiazhuang , Hebei Province , China.
Nutr Cancer. 2018 Feb-Mar;70(2):204-212. doi: 10.1080/01635581.2018.1412474. Epub 2017 Dec 26.
Observational studies on the association between fish and poultry intake and the risk of total cancer mortality have been reported with mixed results. Thus, we aimed to assess this association by conducting a meta-analysis of prospective studies. We performed a literature search on PubMed database through February 1, 2017 to identify relative prospective studies. A random-effects model was used to calculate the summary estimates. We identified fourteen prospective studies involving 2,378,204 participants and 96,712 cancer mortality events. Comparing the highest category of consumption with lowest category, pooled relative risk (RR) of total cancer mortality was 0.99 (95% confidence interval [CI], 0.94-1.05) for fish (10 studies) and 0.96 (95% CI, 0.93-1.00) for poultry (8 studies), respectively. However, we failed to identify any dose-response association based on a limited number of eligible studies, with a pooled RR of 0.98 (95% CI, 0.92-1.05) and 0.97 (95% CI, 0.88-1.07) for each 100 g per day increment in fish and poultry consumption, respectively. In summary, this meta-analysis indicates that consumption of either fish or poultry is not substantially associated with lower risk of total cancer mortality. The observed weak inverse association for high poultry consumption needs to be verified in additional large prospective studies.
关于鱼类和家禽摄入量与总癌症死亡率风险之间关联的观察性研究报告结果不一。因此，我们旨在通过对前瞻性研究进行荟萃分析来评估这种关联。我们在PubMed数据库中进行了文献检索，截至2017年2月1日，以确定相关的前瞻性研究。采用随机效应模型计算汇总估计值。我们确定了14项前瞻性研究，涉及2378204名参与者和96712例癌症死亡事件。将最高消费类别与最低消费类别进行比较，鱼类（10项研究）的总癌症死亡率合并相对风险（RR）为0.99（95%置信区间[CI]，0.94 - 1.05），家禽（8项研究）为0.96（95%CI，0.93 - 1.00）。然而，基于有限数量的合格研究，我们未能发现任何剂量反应关联，鱼类和家禽消费每天每增加100克，合并RR分别为0.98（95%CI，0.92 - 1.05）和0.97（95%CI，0.88 - 1.07）。总之，这项荟萃分析表明，食用鱼类或家禽与降低总癌症死亡率风险并无实质性关联。对于高家禽消费所观察到的微弱反向关联需要在更多大型前瞻性研究中加以验证。
