Rubin E M, Scantlen G E, Chapman G A, Eldridge M, Menendez R, Wanner A
Pulmonary Division, University of Miami, FL.
Pediatr Pulmonol. 1989;6(2):122-6. doi: 10.1002/ppul.1950060213.
This study was designed to investigate the effect of an experimental low-energy chest wall oscillator and of a commercial chest percussor on central airway mucociliary clearance. Five normal dogs were anesthetized, intubated, and placed supine in a trough to which the oscillator or percussor was mounted. Tracheal mucus velocity (TMV) was measured by radiopaque particle or charcoal spot movement. The commercial percussor (a fixed sinusoidal device) used at its minimum frequency of 40 Hz, produced a mean (+/- SE) maximum expiratory flow rate of 0.25 +/- 0.04 L/sec at the airway opening, and had no measurable effect on TMV. The experimental oscillator, when operated at a level sufficient to generate flows of 2-3 L/sec, and with an unbiased 13-Hz sine wave (estimated energy, 150 W), increased mean TMV to 204 +/- 13% of control (P less than 0.003); the percent increase was independent of baseline TMV. We conclude that moderate oscillatory power applied to the chest wall can enhance mucus clearance in central airways, but that currently available commercial percussors may not meet the mechanical requirements for this effect.
本研究旨在调查一种实验性低能量胸壁振荡器和一种商用胸部叩击器对中央气道黏液纤毛清除功能的影响。对5只正常犬进行麻醉、插管，然后使其仰卧于安装有振荡器或叩击器的水槽中。通过不透X线颗粒或炭斑移动来测量气管黏液速度（TMV）。商用叩击器（一种固定正弦波装置）以其最低频率40Hz使用时，在气道开口处产生的平均（±标准误）最大呼气流量为0.25±0.04L/秒，且对TMV没有可测量的影响。实验性振荡器在足以产生2 - 3L/秒气流的水平下运行，并采用无偏13Hz正弦波（估计能量为150W）时，可使平均TMV增加至对照值的204±13%（P<0.003）；增加的百分比与基线TMV无关。我们得出结论，施加于胸壁的适度振荡功率可增强中央气道的黏液清除功能，但目前市售的商用叩击器可能无法满足产生这种效果的机械要求。
