Walravens P A, Hambidge K M, Koepfer D M
Department of Pediatrics, University of Colorado Health Sciences Center, Denver 80262.
Pediatrics. 1989 Apr;83(4):532-8.
The objective of this study was to determine whether zinc deficiency is one of the factors involved in nutritional failure to thrive in infants and toddlers. Participants were selected on the basis of anthropometric criteria, particularly a decline in weight velocity preceding changes in length gains. The investigation was designed as a double-blind, randomized, pair-matched, controlled study of dietary zinc supplementation of 6 months' duration. Anthropometric data were collected at 0, 1, 3, and 6 months. Twenty-five pairs of infants completed the project. When compared with placebo-treated control children, the zinc-supplemented group (combined sexes) and the supplemented boys showed significant improvements in standard deviation scores for weight for all three intervals, the largest differences occurring for the 0- to 3-month interval (P less than or equal to .0001). The zinc-supplemented girls demonstrated a trend toward improvements in changes in standard deviation scores for weight (P = .056). There were no differences in length gains for either boys or girls. This improvement in weight gains after zinc supplementation demonstrates that mild zinc deficiency can be one of the etiologic factors in nutritional failure to thrive during infancy.
本研究的目的是确定锌缺乏是否是婴幼儿营养性生长发育不良的相关因素之一。根据人体测量标准选择参与者，特别是在身长增长变化之前体重增长速度下降的情况。该研究设计为一项为期6个月的双盲、随机、配对匹配、对照的膳食锌补充研究。在0、1、3和6个月时收集人体测量数据。25对婴儿完成了该项目。与接受安慰剂治疗的对照儿童相比，补充锌组（男女混合）和补充锌的男孩在所有三个时间段的体重标准差评分均有显著改善，0至3个月时间段的差异最大（P≤0.0001）。补充锌的女孩在体重标准差评分变化方面有改善趋势（P = 0.056）。男孩和女孩的身长增长均无差异。补充锌后体重增加的改善表明，轻度锌缺乏可能是婴儿期营养性生长发育不良的病因之一。
