Lipid and Membrane Biology Group, UCL Division of Medicine, Royal Free Campus, University College London, London, NW3 2PF, UK.
Bioessays. 2018 Feb;40(2). doi: 10.1002/bies.201700145. Epub 2017 Dec 27.
The type II phosphatidylinositol 4-kinases (PI4KIIs) produce the lipid phosphatidylinositol 4-phosphate (PtdIns4P) and participate in a confusing variety of membrane trafficking and signaling roles. This review argues that both historical and contemporary evidence supports the function of the PI4KIIs in numerous trafficking pathways, and that the key to understanding the enzymatic regulation is through membrane interaction and the intrinsic membrane environment. By summarizing new research and examining the trafficking roles of the PI4KIIs in the context of recently solved molecular structures, I highlight how mechanisms of PI4KII function and regulation are providing insights into the development of cancer and in neurological disease. I present an integrated view connecting the cell biology, molecular regulation, and roles in whole animal systems of these increasingly important proteins.
II 型磷酸肌醇 4-激酶（PI4KIIs）产生脂质肌醇 4-磷酸（PtdIns4P），并参与多种膜运输和信号转导作用。本综述认为，历史和当代的证据都支持 PI4KIIs 在众多运输途径中的作用，而理解酶调节的关键是通过膜相互作用和固有膜环境。通过总结新的研究，并在最近解决的分子结构背景下研究 PI4KIIs 的运输作用，我强调了 PI4KII 功能和调节机制如何为癌症和神经疾病的发展提供新的见解。我提出了一个综合的观点，将这些日益重要的蛋白质的细胞生物学、分子调节和在整体动物系统中的作用联系起来。
