The Jesse Z. and Sara Lea Shafer Institute for Endocrinology and Diabetes, National Center for Childhood Diabetes, Schneider Children's Medical Center of Israel, Petah Tikva, Israel.
Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
Acta Paediatr. 2018 Apr;107(4):666-671. doi: 10.1111/apa.14205. Epub 2018 Jan 17.
Nutrition and sleep are prerequisites for linear growth and we addressed the under-researched role of sleep in this equation.
This was a prospective randomised, double-blinded, placebo-controlled study of nutritional supplements in 164 healthy lean, short, prepubertal children with 83 in the supplement group and 81 in the placebo group. From November 2010 to November 2013, we focussed on children aged three to nine years referred for specialist growth assessments to the Schneider Children's Medical Center, Israel. Progress was assessed using anthropometric measurements, sleep questionnaires and three-day food diaries at baseline and after the six-month intervention.
Children in the supplement group who took at least 50% of the recommended dose had shorter sleep latency than those who did not (p = 0.046). Children who fell asleep in less than 15 minutes had significantly improved standard deviation scores for weight (0.25 ± 0.34 versus 0.07 ± 0.36, p = 0.044) and height (0.09 ± 0.13 versus 0.03 ± 0.13, p = 0.057) than those who took longer to fall asleep. Positive correlations were found between mean sleep duration and caloric and macronutrient intake per kilogram.
Adequate nutritional intake was associated with better sleep patterns and may enhance linear growth.
营养和睡眠是线性生长的前提条件,我们研究了睡眠在这一过程中未被充分研究的作用。
这是一项前瞻性随机、双盲、安慰剂对照研究,研究对象为 164 名健康、消瘦、青春期前的儿童,其中 83 名儿童服用营养补充剂,81 名儿童服用安慰剂。从 2010 年 11 月到 2013 年 11 月,我们专注于因生长问题到以色列施耐德儿童医疗中心接受专科评估的 3 至 9 岁儿童。使用人体测量学测量、睡眠问卷和为期三天的食物日记在基线和六个月干预后评估进展情况。
服用至少 50%推荐剂量的补充剂的儿童比未服用的儿童入睡潜伏期更短(p = 0.046)。入睡时间少于 15 分钟的儿童体重标准差评分显著提高(0.25 ± 0.34 与 0.07 ± 0.36,p = 0.044),身高标准差评分也显著提高(0.09 ± 0.13 与 0.03 ± 0.13,p = 0.057),而入睡时间较长的儿童则没有改善。平均睡眠时间与每公斤热量和宏量营养素摄入呈正相关。
充足的营养摄入与更好的睡眠模式相关,并可能促进线性生长。