Department of Radiation Oncology, Ajou University School of Medicine, Suwon, South Korea.
Office of Biostatistics, Ajou University School of Medicine, South Korea.
Psychooncology. 2018 Mar;27(3):1021-1026. doi: 10.1002/pon.4628. Epub 2018 Jan 26.
The aim of this time-dependent study was to analyze the prevalence of mental disorders in ovarian cancer survivors using claims data in South Korea.
We confirmed mental disorders in a nationwide cohort of 9763 patients who were diagnosed with ovarian cancer between January 1, 2010 and December 31, 2014. We categorized the prevalence of mental disorders based on the age and the time of diagnosis.
A total of 821 ovarian cancer patients were diagnosed with a mental disorder, 1 year prior to the cancer diagnosis. Of those patients, 311 were diagnosed with depression (37.9%) and 245 with anxiety (29.8%) during their first visit. The overall frequency of mental disorders peaked within 2 months after the cancer diagnosis. The highest rate of increase after diagnosis was noted in stress reaction/adjustment disorders. While depression was relatively high (40.4%) in the younger age group under 60 years, anxiety was higher (39.4%) in the elderly group over 60 years old. Age was a significant predictive factor for mental disorders (P = 0.002), and patients over 50 years were at a higher risk for mental disorders (hazard ratio: 1.29, P = 0.002).
Mental disorders in ovarian cancer survivors showed different patterns of prevalence depending on age at the time of diagnosis and the nature of disease. Timely diagnosis and intervention for psychological distress could increase the quality of life for ovarian cancer survivors.
本时间依赖性研究旨在使用韩国的索赔数据分析卵巢癌幸存者的精神障碍患病率。
我们在 2010 年 1 月 1 日至 2014 年 12 月 31 日期间确诊患有卵巢癌的 9763 例患者的全国性队列中确认了精神障碍。我们根据年龄和诊断时间对精神障碍的患病率进行了分类。
共有 821 例卵巢癌患者在癌症诊断前 1 年被诊断出患有精神障碍。在这些患者中，有 311 例（37.9%）在首次就诊时被诊断为抑郁症，245 例（29.8%）被诊断为焦虑症。精神障碍的总体频率在癌症诊断后 2 个月内达到峰值。诊断后增加最快的是应激反应/适应障碍。虽然 60 岁以下的年轻组中抑郁症的比例相对较高（40.4%），但 60 岁以上的老年组中焦虑症的比例较高（39.4%）。年龄是精神障碍的显著预测因素（P=0.002），50 岁以上的患者发生精神障碍的风险更高（危险比：1.29，P=0.002）。
卵巢癌幸存者的精神障碍根据诊断时的年龄和疾病性质呈现不同的流行模式。及时对心理困扰进行诊断和干预可以提高卵巢癌幸存者的生活质量。
