Department of Psychiatry, Katip Celebi University, Ataturk Training and Research Hospital, Turkey.
Department of Psychiatry, Medipol University Health Research and Administration Center, Sefakoy Hospital, Istanbul, Turkey.
Addict Biol. 2019 Mar;24(2):265-274. doi: 10.1111/adb.12599. Epub 2017 Dec 27.
We aimed to examine the whole-brain white matter connectivity and local topology of reward system nodes in patients with alcohol use disorder (AUD) and unaffected siblings, relative to healthy comparison individuals. Diffusion-weighted magnetic resonance imaging scans were acquired from 18 patients with AUD, 15 unaffected siblings of AUD patients and 15 healthy controls. Structural networks were examined using network-based statistic and connectomic analysis. Connectomic analysis showed a significant ordered difference in normalized rich club organization (AUD < Siblings < Controls). We also found rank ordered differences (Control > Sibling > AUD) for both nodal clustering coefficient and nodal local efficiency in reward system nodes, particularly left caudate, right putamen and left hippocampus. Network-based statistic analyses showed that AUD group had significantly weaker connectivity than controls in the right hemisphere, mostly in the edges connecting putamen and hippocampus with other brain regions. Our results suggest that reward system network abnormalities, especially in subcortical structures, and impairments in rich-club organization might be related to the familial predisposition for AUD.
我们旨在研究酒精使用障碍（AUD）患者及无 AUD 家族史的同胞与健康对照者的全脑白质连接和奖励系统节点的局部拓扑结构。从 18 名 AUD 患者、15 名 AUD 患者无 AUD 家族史的同胞和 15 名健康对照者中采集了弥散加权磁共振成像扫描数据。使用基于网络的统计学和连接组学分析检查了结构网络。连接组学分析显示，归一化丰富俱乐部组织（AUD<同胞<对照）存在显著的有序差异。我们还发现奖励系统节点的节点聚类系数和节点局部效率呈等级有序差异（对照>同胞>AUD），特别是左侧尾状核、右侧壳核和左侧海马体。基于网络的统计学分析显示，AUD 组与对照组相比，右侧半球的连接强度明显较弱，主要是壳核和海马体与其他脑区之间的边缘连接较弱。我们的结果表明，奖励系统网络异常，特别是皮质下结构，以及丰富俱乐部组织的损伤，可能与 AUD 的家族易感性有关。
