Cancer Center, Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Department of Medical Imaging, Fourth Hospital of Hebei Medical University, Shijiazhuang, China.
Thorac Cancer. 2018 Feb;9(2):262-272. doi: 10.1111/1759-7714.12575. Epub 2017 Dec 27.
Worldwide breast cancer incidence correlates with socioeconomic status and increases in parallel with westernization, however urban-rural disparity and trends have not been adequately investigated in China.
The age standardized rate (ASR) of female breast cancer by population-based cancer registration was compared between urban Shijiazhuang city and rural Shexian County in relation to socioeconomic status. The increasing trend of breast cancer in Shexian County from 2000-2015 was examined using Joinpoint analysis and the correlation with gross domestic product (GDP) per capita was analyzed.
In 2012, the ASR of female breast cancer in Shijiazhuang was more than three times higher than in Shexian County (45.5/1 00 000 vs.13.8/1 00 000; P < 0.01) when the GDP per capita was 2.6 times higher (US$6964.80 vs. US$2700). In parallel with rapid socioeconomic development and urbanization, the biennial ASR of female breast cancer in Shexian county has increased significantly from 2.8/1 00 000 in 2000-2001 to 17.3/1 00 000 in 2014-2015, with an average biennial percent change of +10.2% (P < 0.01). The Pearson correlation between ASR and GDP was significantly positive (r = 0.94, P < 0.01).
The incidence of breast cancer in women in China is increasing along with lifestyle westernization and changing reproductive patterns associated with socioeconomic development and urbanization. Urgent prevention measures, including the development of a healthy diet, giving birth at a younger age, an increase in breastfeeding, limiting menopause estrogen therapy, and control of alcohol consumption, are required.
全球范围内，乳腺癌的发病率与社会经济地位相关，且随着西方化进程的推进而呈上升趋势。然而，中国的城乡差距和发展趋势尚未得到充分研究。
通过基于人群的癌症登记，比较了城市石家庄市和农村涉县的女性乳腺癌年龄标准化发病率（ASR）与社会经济地位的关系。使用 Joinpoint 分析方法研究了涉县从 2000 年到 2015 年乳腺癌发病率的上升趋势，并分析了与人均国内生产总值（GDP）的相关性。
2012 年，石家庄市女性乳腺癌的 ASR 是涉县的三倍多（45.5/100000 对 13.8/100000；P<0.01），而人均 GDP 则高 2.6 倍（6964.80 美元对 2700 美元）。随着社会经济的快速发展和城市化进程的推进，涉县女性乳腺癌的两年 ASR 显著增加，从 2000-2001 年的 2.8/100000 增加到 2014-2015 年的 17.3/100000，平均两年间变化率为+10.2%（P<0.01）。ASR 与 GDP 之间的皮尔逊相关系数显著为正（r=0.94，P<0.01）。
中国女性乳腺癌的发病率随着生活方式的西方化以及与社会经济发展和城市化相关的生育模式的变化而增加。迫切需要采取预防措施，包括制定健康饮食、鼓励年轻生育、增加母乳喂养、限制更年期雌激素治疗以及控制酒精摄入等。
