Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, Texas.
Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, Texas.
Wiley Interdiscip Rev RNA. 2018 Mar;9(2). doi: 10.1002/wrna.1459. Epub 2017 Dec 27.
Diabetes is a debilitating health care problem affecting 422 million people around the world. Diabetic patients suffer from multisystemic complications that can cause mortality and morbidity. Recent advancements in high-throughput next-generation RNA-sequencing and computational algorithms led to the discovery of aberrant posttranscriptional gene regulatory programs in diabetes. However, very little is known about how these regulatory programs are mis-regulated in diabetes. RNA-binding proteins (RBPs) are important regulators of posttranscriptional RNA networks, which are also dysregulated in diabetes. Human genetic studies provide new evidence that polymorphisms and mutations in RBPs are linked to diabetes. Therefore, we will discuss the emerging roles of RBPs in abnormal posttranscriptional gene expression in diabetes. Questions that will be addressed are: Which posttranscriptional mechanisms are disrupted in diabetes? Which RBPs are responsible for such changes under diabetic conditions? How are RBPs altered in diabetes? How does dysregulation of RBPs contribute to diabetes? Can we target RBPs using RNA-based methods to restore gene expression profiles in diabetic patients? Studying the evolving roles of RBPs in diabetes is critical not only for a comprehensive understanding of diabetes pathogenesis but also to design RNA-based therapeutic approaches for diabetic complications. WIREs RNA 2018, 9:e1459. doi: 10.1002/wrna.1459 This article is categorized under: RNA in Disease and Development > RNA in Disease RNA Processing > Splicing Regulation/Alternative Splicing Translation > Translation Regulation.
糖尿病是一种影响全球 4.22 亿人的衰弱性医疗保健问题。糖尿病患者患有多种系统性并发症，可导致死亡率和发病率。高通量下一代 RNA 测序和计算算法的最新进展导致发现了糖尿病中异常的转录后基因调控程序。然而，对于这些调控程序在糖尿病中如何失调知之甚少。RNA 结合蛋白 (RBP) 是转录后 RNA 网络的重要调节剂，在糖尿病中也失调。人类遗传研究提供了新的证据，表明 RBP 中的多态性和突变与糖尿病有关。因此，我们将讨论 RBP 在糖尿病中异常转录后基因表达中的新兴作用。将要解决的问题是：哪些转录后机制在糖尿病中被破坏？哪些 RBP 在糖尿病条件下负责这种变化？RBP 在糖尿病中如何改变？RBP 的失调如何导致糖尿病？我们能否使用基于 RNA 的方法靶向 RBP 以恢复糖尿病患者的基因表达谱？研究 RBP 在糖尿病中的不断演变的作用不仅对于全面了解糖尿病发病机制至关重要，而且对于设计用于治疗糖尿病并发症的基于 RNA 的治疗方法也至关重要。WIREs RNA 2018, 9:e1459. doi: 10.1002/wrna.1459 本文归入以下类别: RNA 在疾病与发展 > RNA 在疾病中 RNA 加工 > 剪接调控/可变剪接 翻译 > 翻译调控。
