Ebrahimi Moein, Ahmadieh Hamid, Rezaei Kanavi Mozhgan, Safi Sare, Alipour-Parsa Saeed, Advani Soroor, Sorenson Christine M, Sheibani Nader
School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Ophthalmic Research Center, Research Institute for Ophthalmology and Vision Science, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Front Med (Lausanne). 2025 Jan 8;11:1497750. doi: 10.3389/fmed.2024.1497750. eCollection 2024.
The growing global prevalence of diabetes mellitus (DM), along with its associated complications, continues to rise. When clinically detected most DM complications are irreversible. It is therefore crucial to detect and address these complications early and systematically in order to improve patient care and outcomes. The current clinical practice often prioritizes DM complications by addressing one complication while overlooking others that could occur. It is proposed that the commonly targeted cell types including vascular cells, immune cells, glial cells, and fibroblasts that mediate DM complications, might share early responses to diabetes. In addition, the impact of one complication could be influenced by other complications. Recognizing and focusing on the shared early responses among DM complications, and the impacted cellular constituents, will allow to simultaneously address all DM-related complications and limit adverse treatment impacts. This review explores the current understanding of shared pathological signaling mechanisms among DM complications and recognizes new concepts that will benefit from further investigation in both basic and clinical settings. The ultimate goal is to develop more comprehensive treatment strategies, which effectively impact DM complications in multiple organs and improve patient care and outcomes.
全球糖尿病（DM）患病率及其相关并发症持续上升。临床上检测到的大多数糖尿病并发症是不可逆的。因此，为了改善患者护理和治疗结果，早期系统地检测和处理这些并发症至关重要。当前的临床实践通常优先处理一种糖尿病并发症，而忽略了可能出现的其他并发症。有人提出，介导糖尿病并发症的常见靶细胞类型，包括血管细胞、免疫细胞、神经胶质细胞和成纤维细胞，可能对糖尿病有共同的早期反应。此外，一种并发症的影响可能会受到其他并发症的影响。认识并关注糖尿病并发症之间共同的早期反应以及受影响的细胞成分，将有助于同时处理所有与糖尿病相关的并发症，并限制不良治疗影响。本综述探讨了目前对糖尿病并发症之间共同病理信号机制的理解，并认识到一些将受益于基础和临床进一步研究的新概念。最终目标是制定更全面的治疗策略，有效影响多个器官的糖尿病并发症，改善患者护理和治疗结果。
