Wang Julia, Colson Yolonda L, Grinstaff Mark W
Departments of Biomedical Engineering and Chemistry, Boston University, Boston, MA, 02215, USA.
Division of Thoracic Surgery, Department of Surgery, Brigham and Women's Hospital, Boston, MA, 02115, USA.
Adv Healthc Mater. 2018 Apr;7(7):e1701096. doi: 10.1002/adhm.201701096. Epub 2017 Dec 27.
The fabrication and performance of mechanically responsive multilayer superhydrophobic composites are reported. The application of tensile strain triggers the release of small molecules and proteins from these composites, with different tensile strain magnitudes and coating thickness influencing agent release. These mechanoresponsive composites consist of an absorbent drug core surrounded by an electrosprayed superhydrophobic protective coating that limits drug release in the absence of tensile strain. Coating thickness and applied tensile strain control release of chemotherapeutic cisplatin and enzyme β-galactosidase, as measured by atomic absorption and UV-vis spectrophotometry, respectively, with preserved in vitro activity. Such mechanically responsive drug delivery devices, when coupled to existing dynamic mechanical forces in the body or integrated with mechanical medical devices, such as stents, will provide local controlled dosing.
报道了机械响应性多层超疏水复合材料的制备及其性能。施加拉伸应变会触发这些复合材料中小分子和蛋白质的释放，不同的拉伸应变幅度和涂层厚度会影响药物释放。这些机械响应性复合材料由一个吸收性药物核心组成，其周围是通过电喷雾形成的超疏水保护涂层，该涂层在没有拉伸应变的情况下限制药物释放。通过原子吸收法和紫外可见分光光度法分别测定，涂层厚度和施加的拉伸应变可控制化疗药物顺铂和酶β-半乳糖苷酶的释放，且体外活性得以保留。这种机械响应性药物递送装置，当与体内现有的动态机械力相结合或与机械医疗装置（如支架）集成时，将实现局部控释给药。
