Díaz Del Arco Cristina, Ortega Medina Luis, Subhi-Issa Ahmad Issa
Department of Surgical Pathology, Hospital Clínico San Carlos, Madrid, Spain.
Diagn Cytopathol. 2018 Jun;46(6):528-531. doi: 10.1002/dc.23882. Epub 2017 Dec 27.
Heterotopic neural tissue (HNT) has been identified in many sites. In our literature review, we have found only two cases of HNT located in the retroperitoneum. As far as we know, cytological features of HNT have not been described. We here report a case of retroperitoneal HNT diagnosed by fine-needle aspiration (FNA) cytology and subsequent resection. Our patient was a male infant born at 26 weeks' gestation. A retroperitoneal solid-cystic lesion measuring 3.8 cm was identified by abdominal ultrasound. FNA was performed and cytology showed highly cellular smears with single cells and masses of fibrillary material. Cells were small with rounded irregular nuclei and variable cytoplasm. Multinucleated cells, cells with neuronal morphology, calcifications, and hemosiderophages could also be seen. The lesion was excised and histology showed fibrillary areas, glial cells, neurons, and ependymal cells. Synaptophysin, GFAP, and EMA were expressed in distinct areas and cell types. No recurrences were observed.
异位神经组织（HNT）已在许多部位被发现。在我们的文献综述中，仅发现两例位于腹膜后的HNT。据我们所知，尚未有关于HNT细胞学特征的描述。我们在此报告一例经细针穿刺（FNA）细胞学检查及后续切除确诊的腹膜后HNT病例。我们的患者是一名孕26周出生的男婴。腹部超声检查发现一个大小为3.8厘米的腹膜后实性囊性病变。进行了FNA检查，细胞学检查显示涂片细胞丰富，有单个细胞和纤维状物质团块。细胞较小，核呈圆形且不规则，胞质可变。还可见多核细胞、具有神经元形态的细胞、钙化和含铁血黄素巨噬细胞。病变被切除，组织学检查显示有纤维区域、神经胶质细胞、神经元和室管膜细胞。突触素、胶质纤维酸性蛋白（GFAP）和上皮膜抗原（EMA）在不同区域和细胞类型中表达。未观察到复发情况。
