Mayrovitz Harvey N, Wong Jennifer, Fasen Madeline
College of Medical Sciences, Nova Southeastern University, Fort Lauderdale, FL, USA.
J Cosmet Dermatol. 2018 Dec;17(6):1262-1270. doi: 10.1111/jocd.12477. Epub 2017 Dec 27.
Quantitative assessment of possible linkages between skin's firmness and water content is useful for cosmetic and clinical purposes and to better understand features of advancing age.
Our goals were to characterize age-related differential features in skin firmness in women and determine the relationship between skin firmness and indices of skin water.
Skin firmness was quantified using handheld devices that measure the force to indent skin 0.3 and 1.3 mm (F0.3 and F1.3). Skin hydration was quantified using handheld devices that measured tissue dielectric constant (TDC) at 300 MHz to skin depths of 0.5 and 2.0-2.5 mm. All parameters were measured bilaterally in the jowl area and volar forearm of 60 women grouped by age <45 years (YOUNG) and ≥45 years old (MATURE).
All measured parameters were bilaterally symmetrical at jowl and forearm. Forearm and jowl indentation forces were greater in YOUNG with statistically significant declines with advancing age with regression relations most evident at shallower indentation depths (P < .001). Quantitative relations for arm and jowl were F = 0.256 × AGE + 32.7 mN and F = -0.07 × AGE + 17.7 mN. Firmness was related to TDC values only when indentation force and TDC were assessed on the arm at the shallowest skin depths, as weakly related to firmness and was observed to change with age only when measured to a depth of 0.5 mm represented by TDC5 = 0.096 × AGE + 32.7.
Experimental finding show clear differences in skin firmness between age-groups with skin hydration playing a minor role. Possible explanations and suggestions for further studies are provided.
对皮肤紧致度与水分含量之间可能存在的联系进行定量评估,对于美容和临床目的以及更好地理解衰老特征具有重要意义。
我们的目标是描述女性皮肤紧致度与年龄相关的差异特征,并确定皮肤紧致度与皮肤水分指标之间的关系。
使用手持设备对皮肤紧致度进行量化,该设备可测量使皮肤凹陷0.3毫米和1.3毫米所需的力(F0.3和F1.3)。使用手持设备对皮肤水合作用进行量化,该设备可在300兆赫兹频率下测量至皮肤深度0.5毫米和2.0 - 2.5毫米处的组织介电常数(TDC)。在60名按年龄分为<45岁(年轻组)和≥45岁(成熟组)的女性的下颌区域和掌侧前臂双侧测量所有参数。
在下颌和前臂,所有测量参数双侧对称。年轻组的前臂和下颌压痕力更大,随着年龄增长有统计学显著下降,回归关系在较浅压痕深度时最为明显(P <.001)。手臂和下颌的定量关系分别为F = 0.256×年龄 + 32.7毫牛和F = -0.07×年龄 + 17.7毫牛。仅当在最浅皮肤深度的手臂上评估压痕力和TDC时,紧致度才与TDC值相关,与紧致度的相关性较弱,并且仅当测量深度为0.5毫米(由TDC5 = 0.096×年龄 + 32.7表示)时才观察到随年龄变化。
实验结果表明不同年龄组之间皮肤紧致度存在明显差异,皮肤水合作用起次要作用。提供了可能的解释和进一步研究的建议。