Kollai M, Koizumi K
Department of Physiology, State University of New York, SUNY Health Science Center, Brooklyn 11203.
Pflugers Arch. 1989 Feb;413(4):365-71. doi: 10.1007/BF00584485.
The effects of ascending stepwise pressure changes in the isolated carotid sinuses on cardiac vagal and sympathetic nerve activities were studied in anesthetized, open chest dogs. The steady state responses of the cardiac vagal and the sympathetic nerve activity and arterial blood pressure were plotted against the sinus pressure and the relations were approximated by the normal distribution function (response curve). The sinus pressure- vs. "reflex gain" relations (reflex gain curve) were approximated by the normal density function. The maximum gain and the "range of change" were found to be greater for the vagal than for the sympathetic and arterial pressure responses. The sinus pressure values derived from "response curves" and "reflex gain curves" for vagal and sympathetic nerve responses were close to each other, while these values and those obtained from arterial pressure responses were considerably apart. It was concluded that: (1) The cardiac vagal neurons are more sensitive to the baroreceptor input than the sympathetic neurons; (2) The similar type of baroreceptor afferent inputs reach the cardiac vagal and the sympathetic structures which are controlling the autonomic outflows.
在麻醉开胸犬身上研究了离体颈动脉窦内逐步上升的压力变化对心脏迷走神经和交感神经活动的影响。将心脏迷走神经和交感神经活动以及动脉血压的稳态反应与窦内压力作图，并用正态分布函数（反应曲线）拟合这些关系。窦内压力与“反射增益”的关系（反射增益曲线）用正态密度函数拟合。发现迷走神经的最大增益和“变化范围”比交感神经和动脉血压反应的更大。迷走神经和交感神经反应的“反应曲线”和“反射增益曲线”得出的窦内压力值彼此接近，而这些值与从动脉血压反应获得的值相差很大。得出结论：（1）心脏迷走神经神经元比交感神经神经元对压力感受器输入更敏感；（2）类似类型的压力感受器传入输入到达控制自主神经输出的心脏迷走神经和交感神经结构。
