Department of Theoretical Biophysics, Max Planck Institute of Biophysics , Max-von-Laue Strasse 3, 60438 Frankfurt am Main, Germany.
Department of Theory and Bio-Systems, Max Planck Institute of Colloids and Interfaces , Science Park Golm, 14424 Potsdam, Germany.
Nano Lett. 2018 Feb 14;18(2):1259-1263. doi: 10.1021/acs.nanolett.7b04855. Epub 2018 Jan 8.
Besides direct particle-particle interactions, nanoparticles adsorbed to biomembranes experience indirect interactions that are mediated by the membrane curvature arising from particle adsorption. In this Letter, we show that the curvature-mediated interactions of adsorbed Janus particles depend on the initial curvature of the membrane prior to adsorption, that is, on whether the membrane initially bulges toward or away from the particles in our simulations. The curvature-mediated interaction can be strongly attractive for Janus particles adsorbed to the outside of a membrane vesicle, which initially bulges away from the particles. For Janus particles adsorbed to the vesicle inside, in contrast, the curvature-mediated interactions are repulsive. We find that the area fraction of the adhesive Janus particle surface is an important control parameter for the curvature-mediated interaction and assembly of the particles, besides the initial membrane curvature.
除了直接的粒子-粒子相互作用外，吸附在生物膜上的纳米粒子还会经历间接相互作用，这些间接相互作用是由粒子吸附引起的膜曲率介导的。在这封信中，我们表明，吸附的 Janus 粒子的曲率介导相互作用取决于吸附前膜的初始曲率，也就是说，取决于在我们的模拟中，膜在初始时是朝向还是远离粒子凸起。对于吸附在膜囊外部的 Janus 粒子，曲率介导的相互作用可能具有很强的吸引力，因为膜囊最初是远离粒子凸起的。相比之下，对于吸附在囊内的 Janus 粒子，曲率介导的相互作用是排斥的。我们发现，除了初始膜曲率之外，粘性 Janus 粒子表面的面积分数是控制曲率介导相互作用和粒子组装的重要参数。
