Gao Jie, Hou Ruihan, Li Long, Hu Jinglei
Kuang Yaming Honors School, Nanjing University, Nanjing, China.
State Key Laboratory of Nonlinear Mechanics (LNM) and Beijing Key Laboratory of Engineered Construction and Mechanobiology, Institute of Mechanics, Chinese Academy of Sciences, Beijing, China.
Front Mol Biosci. 2021 Dec 22;8:811711. doi: 10.3389/fmolb.2021.811711. eCollection 2021.
Integral or peripheral membrane proteins, or protein oligomers often get close to each other on cell membranes and carry out biological tasks in a collective manner. In addition to electrostatic and van der Waals interactions, those proteins also experience membrane-mediated interactions, which may be necessary for their functionality. The membrane-mediated interactions originate from perturbation of lipid membranes by the presence of protein inclusions, and have been the subject of intensive research in membrane biophysics. Here we review both theoretical and numerical studies of such interactions for membrane proteins and for nanoparticles bound to lipid membranes.
整合膜蛋白或外周膜蛋白，或蛋白质寡聚体常常在细胞膜上彼此靠近，并以集体方式执行生物学任务。除了静电相互作用和范德华相互作用外，这些蛋白质还会经历膜介导的相互作用，这可能对其功能至关重要。膜介导的相互作用源于蛋白质内含物对脂质膜的扰动，一直是膜生物物理学深入研究的主题。在此，我们综述了针对膜蛋白以及与脂质膜结合的纳米颗粒的此类相互作用的理论和数值研究。
