McCarthy Whitney A, Makhijani Reeva, Miller Katherine, Rojas Kristin, Beffa Lindsey, Mathews Cara, Robison Katina, Quddus M Ruhul
1 Women and Infants Hospital of Rhode Island and The Warren Alpert Medical School of Brown University, Providence, RI, USA.
2 Brown University, Providence, RI, USA.
Int J Surg Pathol. 2018 Jun;26(4):377-381. doi: 10.1177/1066896917743010. Epub 2017 Dec 27.
Gastric-type adenocarcinomas of the uterine cervix have been described within the literature in detail; however, the description of gastric-type endometrial adenocarcinomas is a recent development, with only two cases originating from Japan in the world literature to date. According to these prior reports, the recognition of this pattern of differentiation is critical, as it is often associated with deep myoinvasion, positive regional lymph nodes, and poor outcome despite appropriate adjuvant treatment. We present two cases of endometrial adenocarcinoma with gastric-type differentiation in patients from the United States with superficial myoinvasion and positive patient outcomes. Gastric-type differentiation in endometrial adenocarcinomas is rare and likely underrecognized. Continued reporting of these cases is necessary to further understand the natural history and clinical implications of this entity.
子宫颈胃型腺癌在文献中已有详细描述；然而，胃型子宫内膜腺癌的描述是最近才出现的，迄今为止，世界文献中仅有两例来自日本。根据这些先前的报告，识别这种分化模式至关重要，因为它通常与深部肌层浸润、区域淋巴结阳性以及尽管进行了适当的辅助治疗但预后较差有关。我们报告了两例来自美国的具有胃型分化的子宫内膜腺癌患者，其为浅表肌层浸润且患者预后良好。子宫内膜腺癌中的胃型分化很罕见，可能未得到充分认识。持续报告这些病例对于进一步了解该实体的自然史和临床意义是必要的。
