Abada Evi, Banet Natalie, Quddus M Ruhul
Departments of Pathology, Women & Infants Hospital and Warren Alpert Medical School of Brown University, Providence, RI, USA.
Cleveland Clinic Foundation, Cleveland, OH, USA.
Gynecol Oncol Rep. 2022 Oct 7;44:101078. doi: 10.1016/j.gore.2022.101078. eCollection 2022 Dec.
Two precursor lesions are commonly associated with endometrial carcinoma. Atypical endometrial hyperplasia/endometrial intraepithelial neoplasia is a known precursor lesion of endometrial endometrioid carcinoma, while endometrial intraepithelial carcinoma, is a recognized precursor lesion of endometrial high-grade serous carcinoma. Other than these two recognized entities, other rare precursor lesions for endometrial carcinoma do exist, although reported cases are relatively few and not universally recognized. This therefore poses diagnostic challenges in clinical practice. Here, we describe a series of rare precursor lesions of the endometrium identified at our institution, including clear cell and gastrointestinal variants, their morphologic and immunohistochemical characteristics, and review current literature regarding these variants. The information provided may guide the proper diagnosis and ultimately lead to effective clinical management in every-day practice.
两种前驱病变通常与子宫内膜癌相关。非典型子宫内膜增生/子宫内膜上皮内瘤变是子宫内膜样腺癌已知的前驱病变，而子宫内膜上皮内癌是子宫内膜高级别浆液性癌公认的前驱病变。除了这两种已被认可的病变外，确实还存在其他罕见的子宫内膜癌前驱病变，尽管报道的病例相对较少且未得到普遍认可。因此，这在临床实践中带来了诊断挑战。在此，我们描述了在我们机构发现的一系列罕见的子宫内膜前驱病变，包括透明细胞和胃肠道变异型，它们的形态学和免疫组化特征，并回顾了关于这些变异型的当前文献。所提供的信息可能会指导日常实践中的正确诊断并最终实现有效的临床管理。
