骨特异性碱性磷酸酶——一种用于骨骼生长评估的潜在生物标志物。
Bone-specific alkaline phosphatase - a potential biomarker for skeletal growth assessment.
作者信息
Tripathi Tulika, Gupta Prateek, Sharma Jitender, Rai Priyank, Gupta Vinod Kumar, Singh Navneet
机构信息
a Department of Orthodontics and Dentofacial Orthopaedics , Maulana Azad Institute of Dental Sciences , New Delhi , India.
b Department of Biochemistry , Govind Ballabh Pant Institute of Postgraduate Medical Education and Research , New Delhi , India.
出版信息
J Orthod. 2018 Mar;45(1):4-10. doi: 10.1080/14653125.2017.1416571. Epub 2017 Dec 27.
OBJECTIVE
The present study was aimed to assess levels of serum Bone-specific alkaline phosphatase (BALP) and serum Insulin-like growth factor-1 (IGF-1) and comparing with cervical vertebral maturation index (CVMI) stages.
DESIGN
Cross-sectional study.
SETTING
Maulana Azad Institute of Dental Sciences, New Delhi, India.
PARTICIPANTS
150 subjects (75 males and 75 females) in the age group of 8-20 years.
METHODS
Subjects were divided into six CVMI stages. Enzyme-linked immunosorbant assay was performed for the estimation of serum BALP and serum IGF-1 levels. Mann-Whitney U test was performed to compare mean ranks of serum BALP and serum IGF-1 with different CVMI stages. Spearman correlation between serum BALP and serum IGF-1 was done across 6 CVMI stages.
RESULTS
Peak serum IGF-1 levels were found at CVMI stages 4 and 3 for males and females respectively. Peak levels for serum BALP were found at stage 3 for both genders with significant differences from other stages. A statistically significant correlation was seen between serum IGF-1 and serum BALP from CVMI stages 1 to 3 and 4 to 6 (p < .01).
CONCLUSIONS
BALP showed promising results and can be employed as a potential biomarker for the estimation of growth status.
目的
本研究旨在评估血清骨特异性碱性磷酸酶（BALP）和血清胰岛素样生长因子-1（IGF-1）水平，并与颈椎成熟指数（CVMI）分期进行比较。
设计
横断面研究。
地点
印度新德里穆拉纳·阿扎德牙科学院。
参与者
150名年龄在8至20岁之间的受试者（75名男性和75名女性）。
方法
将受试者分为六个CVMI分期。采用酶联免疫吸附测定法评估血清BALP和血清IGF-1水平。进行曼-惠特尼U检验，以比较不同CVMI分期的血清BALP和血清IGF-1的平均秩次。在6个CVMI分期中对血清BALP和血清IGF-1进行斯皮尔曼相关性分析。
结果
男性和女性的血清IGF-1峰值水平分别在CVMI分期4和3时出现。血清BALP的峰值水平在两个性别中均出现在第3期，与其他期有显著差异。在CVMI分期1至3以及4至6中，血清IGF-1和血清BALP之间存在统计学显著相关性（p < 0.01）。
结论
BALP显示出有前景的结果，可作为评估生长状态的潜在生物标志物。
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