Batool Sidra, Noureen Nighat, Kamal Mohammad Amjad
Department of Biosciences, COMSATS Institute of Information Technology, Islamabad, Pakistan.
King Fahd Medical Research Center, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Curr Drug Metab. 2018;19(8):714-720. doi: 10.2174/1389200219666171227205009.
Peptide toxins are naturally occurring rich sources of highly specific bioactive compounds from venomous animals acting on various types of ion channels.
This study mainly highlights targeting of one of the largest families of ion channels i.e. potassium channels via venom toxins.
Data for reported venom toxins from diverse species is gathered and analyzed at sequence and structural extent.
The similarities and differences among toxins have been demonstrated along with structure activity relationship of potassium channels with these toxins.
This review highlights the importance of functionally important residues and structural scaffolds of venoms interacting with potassium channels.
肽毒素是有毒动物中天然存在的丰富来源，含有作用于各种离子通道的高度特异性生物活性化合物。
本研究主要强调通过毒液毒素靶向最大的离子通道家族之一，即钾通道。
收集并在序列和结构层面分析来自不同物种的已报道毒液毒素的数据。
已证明毒素之间的异同以及钾通道与这些毒素的构效关系。
本综述强调了毒液中与钾通道相互作用的功能重要残基和结构支架的重要性。
