Pudroma Xiao, Duoji Gongsang, Grigalavicius Mantas, Jie Duan, Juzeniene Asta
Department of Physics, Tibet University, Lhasa, China.
Department of Mathematics, Tibet University, Lhasa, China.
J Environ Pathol Toxicol Oncol. 2017;36(3):217-228. doi: 10.1615/JEnvironPatholToxicolOncol.2017020213.
Cutaneous melanoma is a deadly skin cancer, resulting from malignant transformation of melanocytes. Long-wave ultraviolet radiation (315-400 nm) is able to damage DNA, cause mutations, and induce melanoma. However, the exact mechanisms of UVA-induced cutaneous melanoma remain a matter of debate. In this review, we give a brief characterization of the most important elements in the photobiology of UVA in melanomagenesis.
皮肤黑色素瘤是一种致命的皮肤癌，由黑素细胞的恶性转化引起。长波紫外线辐射（315 - 400纳米）能够损伤DNA、导致突变并诱发黑色素瘤。然而，UVA诱导皮肤黑色素瘤的确切机制仍存在争议。在这篇综述中，我们简要描述了UVA在黑色素瘤发生中的光生物学中最重要的元素。
