Durham Charis G, Herrington Jon, Seago Susan, Williams Chelsea, Holguin Mark H
Department of Internal Medicine, Baylor Scott & White, Temple, TX, USA.
J Oncol Pharm Pract. 2018 Apr;24(3):221-225. doi: 10.1177/1078155217693425. Epub 2017 Feb 21.
Tumor lysis syndrome is a life-threatening complication that often occurs after administration of cytotoxic therapy, but rarely occurs spontaneously without chemotherapy. This vignette describes a 59-year-old male with known extensive metastatic melanoma who presented to the hospital with spontaneous tumor lysis syndrome. Most spontaneous tumor lysis cases occur in patients with acute leukemias and aggressive lymphomas; however, this rare case depicts a patient with melanoma developing tumor lysis before the administration of chemotherapy.
肿瘤溶解综合征是一种危及生命的并发症，常发生于细胞毒性治疗后，但在无化疗的情况下很少自发发生。本病例描述了一名59岁男性，已知患有广泛转移性黑色素瘤，因自发肿瘤溶解综合征入院。大多数自发肿瘤溶解病例发生在急性白血病和侵袭性淋巴瘤患者中；然而，这个罕见病例描述的是一名黑色素瘤患者在化疗前发生肿瘤溶解。
