1Veterans Affairs (VA) Northwest Network (VISN 20) Mental Illness,Research,Education,and Clinical Center (MIRECC),Veterans Affairs Puget Sound Health Care System,Seattle,Washington.
3San Diego State University/University of California,San Diego (SDSU/UCSD) Joint Doctoral Program in Clinical Psychology,San Diego,California.
J Int Neuropsychol Soc. 2018 Apr;24(4):324-334. doi: 10.1017/S1355617717001217. Epub 2017 Dec 29.
To evaluate prospective and retrospective memory abilities in Operation Enduring Freedom (OEF), Operation Iraqi Freedom (OIF), and Operation New Dawn (OND) Veterans with and without a self-reported history of blast-related mild traumatic brain injury (mTBI).
Sixty-one OEF/OIF/OND Veterans, including Veterans with a self-reported history of blast-related mTBI (mTBI group; n=42) and Veterans without a self-reported history of TBI (control group; n=19) completed the Memory for Intentions Test, a measure of prospective memory (PM), and two measures of retrospective memory (RM), the California Verbal Learning Test-II and the Brief Visuospatial Memory Test-Revised.
Veterans in the mTBI group exhibited significantly lower PM performance than the control group, but the groups did not differ in their performance on RM measures. Further analysis revealed that Veterans in the mTBI group with current PTSD (mTBI/PTSD+) demonstrated significantly lower performance on the PM measure than Veterans in the control group. PM performance by Veterans in the mTBI group without current PTSD (mTBI/PTSD-) was intermediate between the mTBI/PTSD+ and control groups, and results for the mTBI/PTSD- group were not significantly different from either of the other two groups.
Results suggest that PM performance may be a sensitive marker of cognitive dysfunction among OEF/OIF/OND Veterans with a history of self-reported blast-related mTBI and comorbid PTSD. Reduced PM may account, in part, for complaints of cognitive difficulties in this Veteran cohort, even years post-injury. (JINS, 2018, 24, 324-334).
评估有和没有自我报告的爆炸相关轻度创伤性脑损伤 (mTBI) 病史的持久自由行动 (OEF)、伊拉克自由行动 (OIF) 和新黎明行动 (OND) 的退伍军人的前瞻性和回顾性记忆能力。
61 名 OEF/OIF/OND 退伍军人，包括有自我报告的爆炸相关 mTBI 病史的退伍军人 (mTBI 组；n=42) 和没有自我报告的 TBI 病史的退伍军人 (对照组；n=19) 完成了意向记忆测试，这是一种前瞻性记忆 (PM) 的测量方法，以及两种回顾性记忆 (RM) 的测量方法，加利福尼亚语言学习测试-II 和简短视觉空间记忆测试修订版。
mTBI 组的退伍军人表现出明显较低的 PM 表现，而两组在 RM 测量上没有差异。进一步分析表明，患有 PTSD 的 mTBI 组退伍军人 (mTBI/PTSD+) 的 PM 测量表现明显低于对照组。没有当前 PTSD 的 mTBI 组退伍军人 (mTBI/PTSD-) 的 PM 表现介于 mTBI/PTSD+ 和对照组之间，mTBI/PTSD- 组的结果与其他两组均无显著差异。
结果表明，PM 表现可能是有自我报告的爆炸相关 mTBI 和共病 PTSD 病史的 OEF/OIF/OND 退伍军人认知功能障碍的敏感标志物。在这个退伍军人队列中，即使在受伤多年后，PM 减少可能部分解释了认知困难的抱怨。(JINS，2018，24，324-334)。
