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个体内神经认知变异性与创伤后应激障碍合并轻度创伤性脑损伤退伍军人前瞻性记忆的相关性。

Associations between Intra-Individual Neurocognitive Variability and Prospective Memory in Veterans with Mild Traumatic Brain Injury History and Posttraumatic Stress Disorder.

机构信息

Veterans Affairs (VA) Northwest (VISN 20) Mental Illness, Research, Education, and Clinical Center (MIRECC), Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA.

Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA.

出版信息

Arch Clin Neuropsychol. 2022 Aug 23;37(6):1221-1227. doi: 10.1093/arclin/acac014.

Abstract

OBJECTIVE

Mild traumatic brain injury (mTBI) and posttraumatic stress disorder (PTSD) frequently co-occur and are associated with neurocognitive intra-individual variability (IIV) and difficulty with prospective memory (PM). The current study aimed to examine associations between IIV and PM in this comorbid group.

METHOD

Fifty veterans with a history of blast mTBI and current comorbid PTSD completed a standardized neurocognitive battery to measure IIV, and the Memory for Intentions Screening Test measuring PM.

RESULTS

Adjusting for age, education, and race, higher IIV was associated with poorer time-based PM (p < .001, f2 = .34), but not event-based PM. In a subset of the sample with self-report data, higher IIV was associated with poorer self-reported retrospective memory, but not PM.

CONCLUSIONS

Cognitive variability on a standardized neuropsychological battery was associated with strategically demanding PM, which is an ecologically relevant ability and highlights the possible connection between subtle cognitive difficulties in-clinic and those experienced in daily life.

摘要

目的

轻度创伤性脑损伤(mTBI)和创伤后应激障碍(PTSD)经常同时发生,并与神经认知个体内变异性(IIV)和前瞻性记忆(PM)困难有关。本研究旨在探讨这一合并症群体中 IIV 和 PM 之间的关联。

方法

50 名有爆炸 mTBI 病史和当前合并 PTSD 的退伍军人完成了标准化神经认知测试,以测量 IIV,以及测量 PM 的意向记忆筛查测试。

结果

调整年龄、教育程度和种族后,较高的 IIV 与较差的基于时间的 PM 相关(p<0.001,f2=0.34),但与基于事件的 PM 无关。在样本的一个亚组中,具有自我报告数据的样本中,较高的 IIV 与较差的自我报告回溯记忆相关,但与 PM 无关。

结论

标准化神经心理学测试中的认知变异性与策略性要求较高的 PM 相关,这是一种具有生态相关性的能力,突出了在临床中出现的细微认知困难与日常生活中所经历的困难之间的可能联系。

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