Grover Sandeep, Sahoo Swapnajeet, Goyal Manoj Kumar
Department of Psychiatry, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Department of Neurology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Indian J Psychol Med. 2017 Nov-Dec;39(6):823-827. doi: 10.4103/IJPSYM.IJPSYM_68_17.
Comorbidity of idiopathic Parkinson's disease (IPD) and schizophrenia is an uncommon and rare scenario, which often poses a difficult and challenging situation for management. Both the disorders have completely opposite pathophysiology and treatment of one disorder with available pharmacological agents can pose a threat to the other disorder. The situation becomes graver and risk of adverse side effects increases when an individual presents at a later age with both these disorders along with compromised physical and mental health. Of all the available psychopharmacological agents, clozapine has been found to be quite helpful for the management of psychosis without deterioration of existing movement problems of Parkinson's disease. In this case report, we present the case of a 60-year-old female with long-standing paranoid schizophrenia for the last 30 years, who later developed IPD and discuss the various management issues encountered during her treatment.
特发性帕金森病（IPD）与精神分裂症的共病是一种罕见的情况，这常常给治疗带来困难和挑战。这两种疾病具有完全相反的病理生理学，使用现有的药物治疗其中一种疾病可能会对另一种疾病构成威胁。当一个人在晚年同时出现这两种疾病且身心健康受损时，情况会变得更加严重，不良副作用的风险也会增加。在所有可用的精神药物中，已发现氯氮平对治疗精神病很有帮助，同时不会使帕金森病现有的运动问题恶化。在本病例报告中，我们介绍了一名60岁女性的病例，她患有长达30年的偏执型精神分裂症，后来又患上了IPD，并讨论了她治疗期间遇到的各种管理问题。
