Yassin Hany Mahmoud, Abdel Moneim Ahmed Tohamy, Mostafa Bayoumy Ahmed Sherin, Bayoumy Hasan Metwally, Taher Sameh Galal
Department of Anaesthesiology, Faculty of Medicine, Fayoum University, Fayuom, Egypt.
Department of Anaesthesiology, Faculty of Medicine, Benha University, Benha, Egypt.
Anesth Essays Res. 2017 Oct-Dec;11(4):969-975. doi: 10.4103/aer.AER_35_17.
The use of succinylcholine for rapid sequence induction in patients with open globe injuries may be detrimental to the eye.
The aim of this study is to determine if the premedication with magnesium sulfate (MgSO) could attenuate the increase in intraocular pressure (IOP) associated with succinylcholine injection and intubation.
Operation theaters in a tertiary care University Hospital between December 2014 and July 215.
This was a prospective, randomized, parallel three-arm, double-blind, placebo-controlled clinical trial.
One hundred and thirteen patients' physical status ASA Classes I and II underwent elective cataract surgery under general anesthesia.
These patients allocated into three groups: Group C (control group) received 100 ml normal saline, Group M1 received 30 mg/kg MgSO in 100 ml normal saline, and Group M2 received 50 mg/kg MgSO in 100 ml normal saline. IOP, mean arterial pressure (MAP), and heart rate (HR) reported at 5-time points related to study drug administration. In addition, any adverse effects related to MgSO were recorded. Intragroup and between-groups differences were examined by analysis of variance test.
We noticed a significant decrease in IOP in M1 ( = 38) and M2 ( = 37) groups as compared with C group ( = 38) after study drugs infusion, 2 and 5 min after intubation, < 0.001. While the difference between M1 and M2 groups was insignificant, = 0.296 and = 0.647, respectively. There was a significant decrease in MAP and HR in M1 and M2 groups as compared with C group 2 and 5 min after intubation, = 0.01. While the difference between M1 and M2 groups was insignificant, = 1.
MgSO 30 mg/kg as well as 50 mg/kg effectively prevented the rise in IOP, MAP, and HR associated with rapid sequence induction by succinylcholine and endotracheal intubation.
在开放性眼球损伤患者中使用琥珀酰胆碱进行快速顺序诱导可能对眼睛有害。
本研究的目的是确定硫酸镁（MgSO）预处理是否可以减轻与琥珀酰胆碱注射和插管相关的眼内压（IOP）升高。
2014年12月至2015年7月期间，一家三级医疗大学医院的手术室。
这是一项前瞻性、随机、平行三臂、双盲、安慰剂对照临床试验。
113例美国麻醉医师协会（ASA）分级为I级和II级的患者在全身麻醉下接受择期白内障手术。
这些患者被分为三组：C组（对照组）接受100ml生理盐水，M1组接受100ml生理盐水中30mg/kg的MgSO，M2组接受100ml生理盐水中50mg/kg的MgSO。在与研究药物给药相关的5个时间点报告IOP、平均动脉压（MAP）和心率（HR）。此外，记录与MgSO相关的任何不良反应。通过方差分析检验检查组内和组间差异。
我们注意到，在输注研究药物后、插管后2分钟和5分钟，M1组（n = 38）和M2组（n = 37）的IOP与C组（n = 38）相比显著降低，P < 0.001。而M1组和M2组之间的差异不显著，P分别为0.296和0.647。与C组相比，M1组和M2组在插管后2分钟和5分钟时MAP和HR显著降低，P = 0.01。而M1组和M2组之间的差异不显著，P = 1。
30mg/kg以及50mg/kg的MgSO有效预防了与琥珀酰胆碱快速顺序诱导和气管插管相关的IOP、MAP和HR升高。
