Sinha R, Sharma A, Ray B R, Chandiran R, Chandralekha C, Sinha R
Department of Anesthesiology, All India Institute of Medical Sciences, New Delhi, India.
Department of Ophthalmology, All India Institute of Medical Sciences, New Delhi, India.
Saudi J Anaesth. 2016 Jan-Mar;10(1):64-7. doi: 10.4103/1658-354X.169478.
Magnesium sulphate has been used along with local anesthetics in different regional blocks and found to be effective in decreasing the time of onset of the block and increasing the duration of the block.
To evaluate the effect of addition of magnesium sulfate to standard local anesthetics mixture on the time for onset of the globe and lid akinesia for peribulbar block in ophthalmic surgeries.
Sixty patients with American Society of Anesthesiologists status I to III undergoing ophthalmic surgery under peribulbar block were included in this study. Patients were randomized into two groups. Both the groups received 4.5 ml of 2% lidocaine, 4.5 ml of 0.5% bupivacaine with150 IU hyaluronidase. Group NS received normal saline 1 ml in the peribulbar block and Group MS, magnesium sulfate 50 mg in 1 ml normal saline. The onset of akinesia, satisfactory block and complications were observed by an independent observer.
Demographic data was statistically similar. In the Group NS at 3, 5, 10 and 15 min after the block, complete akinesia was seen in 0, 2, 11 and 28 patients respectively. In the Group MS, at 3, 5, 10 and 15 min after the block, complete akinesia was seen in 13, 23, 27 and 28 patients respectively. Patients received magnesium sulfate showed the statistically significant rapid onset of lid and globe akinesia than the control group till 10 min (P < 0.000). None of the patients needed a supplementary block and had complications during the surgery.
Addition of 50 mg of magnesium sulfate to the lidocaine-bupivacaine mixture for peribulbar block decreases the onset of akinesia without any obvious side effect.
硫酸镁已与局部麻醉药一起用于不同的区域阻滞，并被发现可有效缩短阻滞起效时间并延长阻滞持续时间。
评估在标准局部麻醉药混合物中添加硫酸镁对眼科手术球周阻滞时眼球和眼睑运动消失时间的影响。
本研究纳入了60例美国麻醉医师协会分级为I至III级、接受球周阻滞下眼科手术的患者。患者被随机分为两组。两组均接受4.5毫升2%利多卡因、4.5毫升0.5%布比卡因加150国际单位透明质酸酶。NS组在球周阻滞中接受1毫升生理盐水，MS组在1毫升生理盐水中加入50毫克硫酸镁。由一名独立观察者观察运动消失的起效情况、满意的阻滞效果及并发症。
人口统计学数据在统计学上相似。在NS组，阻滞3、5、10和15分钟后，分别有0、2、11和28例患者出现完全运动消失。在MS组，阻滞3、5、10和15分钟后，分别有13、23、27和28例患者出现完全运动消失。直到10分钟，接受硫酸镁的患者比对照组在统计学上显示出眼睑和眼球运动消失起效更快（P < 0.000）。手术期间没有患者需要追加阻滞，也没有出现并发症。
在用于球周阻滞的利多卡因-布比卡因混合物中添加50毫克硫酸镁可缩短运动消失的起效时间，且无任何明显副作用。
