Liu Guodong, Du Qing, Keyal Khusbu, Wang Fang
Department of Ophthalmology, Shanghai Tenth People's Hospital Affiliated to Tongji University School of Medicine, Shanghai 200072, P.R. China.
Exp Ther Med. 2017 Dec;14(6):5387-5394. doi: 10.3892/etm.2017.5227. Epub 2017 Sep 29.
Retinitis pigmentosa (RP) is an inherited retinal disease caused by the degeneration of photoreceptors and retinal pigment epithelium cells within the eye. The present study aimed to evaluate the effectiveness of multicolor imaging as a novel technique for the depiction of morphological features in the macular area of patients with RP. Additionally, the correlation between the size of the macular-sparing area and the best corrected visual acuity (BCVA), central visual field function and subfoveal choroidal thickness (SFCT) was analyzed. A total of 25 individuals with RP (n=50 eyes) and 35 healthy individuals (n=70 eyes) were enrolled in the current study. Images of the macular area were captured using multicolor imaging and traditional fundus photography, and their ability to depict retinal features was compared. The size of the macular-sparing area in patients with RP was measured using built-in measurement software programs. The correlations between the macular-sparing area and the BCVA, visual field and SFCT were analyzed using a Spearman's rank correlation test. The results demonstrated that multicolor imaging revealed clinical features of the macular area in greater detail than traditional fundus photography irrespective of whether the patient also had complications, including cataracts and epiretinal membranes. Multicolor imaging clearly defined the borders of the macular-sparing area corresponding to the relatively intact outer retinal structures on optical coherence tomography images, particularly the status of the ellipsoid zone and external limiting membrane. There was a significant positive correlation between the macular-sparing area and BCVA (r=-0.631; P<0.001), and the visual field in terms of MD (r=0.402; P<0.05) and PSD (r=0.595; P<0.001), however, there was not a statistically significant correlation between the macular-sparing area and SFCT. The present study demonstrated that multicolor imaging is capable of detecting macular changes and complications in patients with RP. Multicolor imaging may be particularly useful in assessing the detailed characteristics of the macular-sparing area, as this appears to be associated with visual function.
视网膜色素变性（RP）是一种遗传性视网膜疾病，由眼内光感受器和视网膜色素上皮细胞的退化引起。本研究旨在评估多色成像作为一种描绘RP患者黄斑区形态特征的新技术的有效性。此外，还分析了黄斑保留区大小与最佳矫正视力（BCVA）、中心视野功能和黄斑下脉络膜厚度（SFCT）之间的相关性。本研究共纳入了25例RP患者（50只眼）和35例健康个体（70只眼）。使用多色成像和传统眼底摄影采集黄斑区图像，并比较它们描绘视网膜特征的能力。使用内置测量软件程序测量RP患者黄斑保留区的大小。使用Spearman等级相关检验分析黄斑保留区与BCVA、视野和SFCT之间的相关性。结果表明，无论患者是否还患有包括白内障和视网膜前膜在内的并发症，多色成像都比传统眼底摄影更能详细显示黄斑区的临床特征。多色成像清晰地界定了黄斑保留区的边界，这些边界与光学相干断层扫描图像上相对完整的视网膜外层结构相对应，特别是椭圆体带和外界膜的状态。黄斑保留区与BCVA之间存在显著正相关（r=-0.631；P<0.001），与视野的平均缺损（MD，r=0.402；P<0.05）和模式标准差（PSD，r=0.595；P<0.001）也存在显著正相关，然而，黄斑保留区与SFCT之间没有统计学上的显著相关性。本研究表明，多色成像能够检测RP患者的黄斑变化和并发症。多色成像在评估黄斑保留区的详细特征方面可能特别有用，因为这似乎与视觉功能有关。
