Fujiwara Kohta, Ikeda Yasuhiro, Murakami Yusuke, Nakatake Shunji, Tachibana Takashi, Yoshida Noriko, Nakao Shintaro, Hisatomi Toshio, Yoshida Shigeo, Yoshitomi Takeshi, Sonoda Koh-Hei, Ishibashi Tatsuro
Department of Ophthalmology Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan 2Department of Ophthalmology, Graduate School of Medical Sciences, Akita University, Akita, Japan.
Department of Ophthalmology Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Invest Ophthalmol Vis Sci. 2016 Aug 1;57(10):4282-6. doi: 10.1167/iovs.16-19686.
Epiretinal membrane (ERM) is a frequent macular complication in patients with retinitis pigmentosa (RP). The etiology of ERM formation in RP is largely unknown. The purpose of this study was to investigate the association between aqueous flare, a surrogate index of intraocular inflammation, and ERM secondary to RP.
We retrospectively studied a total of 206 eyes of 117 patients who were diagnosed with typical RP. Aqueous flare values were measured consecutively in 2012 and 2013 using a laser flare cell meter. Spectral-domain optical coherence tomography images and fundus photographs taken on the same day of the aqueous flare measurements were analyzed for ERM detection.
The mean values of aqueous flare, age, and frequency of male sex were significantly higher in the RP patients with ERM compared with the RP patients without ERM (P < 0.0001, P = 0.007, and P = 0.004, respectively). After adjustment for age and sex, the eyes in the highest quartile of aqueous flare had significantly higher odds of having ERM than those in the lowest quartile (odds ratio [OR], 2.68; 95% confidence interval [CI], 1.04-6.93), and the linear trend across flare levels was significant (P = 0.005). In addition, each 1-log-transformed increase in flare values was associated with an elevation of the likelihood of having ERM (OR, 2.59; 95% CI, 1.33-5.06).
Our analysis demonstrated that elevated aqueous flare is associated with ERM secondary to RP, suggesting that inflammation may be implicated in the pathogenesis of ERM formation in RP.
视网膜前膜（ERM）是色素性视网膜炎（RP）患者常见的黄斑并发症。RP中ERM形成的病因在很大程度上尚不清楚。本研究的目的是调查眼内炎症的替代指标——房水闪光与RP继发的ERM之间的关联。
我们回顾性研究了117例被诊断为典型RP患者的206只眼。在2012年和2013年使用激光闪光细胞仪连续测量房水闪光值。对在房水闪光测量当天拍摄的频域光学相干断层扫描图像和眼底照片进行分析以检测ERM。
与无ERM的RP患者相比，有ERM的RP患者的房水闪光平均值、年龄和男性比例显著更高（分别为P < 0.0001、P = 0.007和P = 0.004）。在对年龄和性别进行调整后，房水闪光处于最高四分位数的眼发生ERM的几率显著高于最低四分位数的眼（优势比[OR]，2.68；95%置信区间[CI]，1.04 - 6.93），并且闪光水平的线性趋势显著（P = 0.005）。此外，闪光值每增加1个对数转换单位与发生ERM的可能性升高相关（OR，2.59；95% CI，1.33 - 5.06）。
我们的分析表明，房水闪光升高与RP继发的ERM相关，提示炎症可能参与了RP中ERM形成的发病机制。
