Jimenez Amanda, Pegueroles Jordi, Carmona-Iragui María, Vilaplana Eduard, Montal Victor, Alcolea Daniel, Videla Laura, Illán-Gala Ignacio, Pané Adriana, Casajoana Anna, Belbin Olivia, Clarimón Jordi, Moizé Violeta, Vidal Josep, Lleó Alberto, Fortea Juan, Blesa Rafael
Endocrinology and Diabetes Department, Obesity Unit, Hospital Clinic de Barcelona, Barcelona, Spain.
Institut d'Investigacions Biomèdiques August Pi Sunyer, Barcelona, Spain.
Oncotarget. 2017 Oct 31;8(62):104706-104716. doi: 10.18632/oncotarget.22218. eCollection 2017 Dec 1.
Weight loss has been proposed as a sign of pre-clinical Alzheimer Disease (AD). To test this hypothesis, we have evaluated the association between longitudinal changes in weight trajectories, cognitive performance, AD biomarker profiles and brain structure in 363 healthy controls from the Alzheimer´s Disease Neuroimaging Initiative (mean follow-up 50.5±30.5 months). Subjects were classified according to body weight trajectory into a weight loss group (WLG; relative weight loss ≥ 5%) and a non-weight loss group (non-WLG; relative weight loss < 5%). Linear mixed effects models were used to estimate the effect of body weight changes on ADAS-Cognitive score across time. Baseline CSF tau/AΔ ratio and AV45 PET uptake were compared between WLG and non-WLG by analysis of covariance. Atrophy maps were compared between groups at baseline and longitudinally at a 2-year follow-up using Freesurfer. WLG showed increased baseline levels of cerebrospinal fluid tau/AΔ ratio, increased PET amyloid uptake and diminished cortical thickness at baseline. WLG also showed faster cognitive decline and faster longitudinal atrophy. Our data support weight loss as a non-cognitive manifestation of pre-clinical AD.
体重减轻已被提出作为临床前阿尔茨海默病（AD）的一个标志。为了验证这一假设，我们评估了来自阿尔茨海默病神经影像倡议组织的363名健康对照者（平均随访时间50.5±30.5个月）体重轨迹的纵向变化、认知表现、AD生物标志物谱和脑结构之间的关联。根据体重轨迹将受试者分为体重减轻组（WLG；相对体重减轻≥5%）和非体重减轻组（非WLG；相对体重减轻<5%）。使用线性混合效应模型来估计体重变化对不同时间点ADAS认知评分的影响。通过协方差分析比较WLG和非WLG之间的基线脑脊液tau/Aβ比值和AV45 PET摄取。使用Freesurfer在基线时以及2年随访时纵向比较两组之间的萎缩图谱。WLG在基线时脑脊液tau/Aβ比值的基线水平升高、PET淀粉样蛋白摄取增加且皮质厚度减小。WLG还表现出更快的认知衰退和更快的纵向萎缩。我们的数据支持体重减轻作为临床前AD的一种非认知表现。
