Leptin Receptors can be an Alternative Target for New Anti-hypertensive Drug Development.
作者信息
Ramkumar Mridula, Kanthlal S K
机构信息
QuintilesIMS, Bengaluru, Karnataka, India.
Department of Pharmacology, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi, Kerala, India.
出版信息
Indian J Endocrinol Metab. 2017 Nov-Dec;21(6):929-930. doi: 10.4103/ijem.IJEM_564_17.
Abstract
摘要
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本文引用的文献
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Elevated plasma immunoreactive leptin levels preexist in healthy offspring of patients with essential hypertension.原发性高血压患者的健康后代中，血浆免疫反应性瘦素水平升高的情况在疾病发生前就已存在。
Am Heart J. 1999 Nov;138(5 Pt 1):922-5. doi: 10.1016/s0002-8703(99)70018-9.
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Is there a role for the ob gene product leptin in essential hypertension?肥胖基因产物瘦素在原发性高血压中起作用吗？
Am J Hypertens. 1998 Nov;11(11 Pt 1):1305-11. doi: 10.1016/s0895-7061(98)00162-9.
3
Human adipose tissue expresses angiotensinogen and enzymes required for its conversion to angiotensin II.人体脂肪组织表达血管紧张素原及其转化为血管紧张素II所需的酶。
J Clin Endocrinol Metab. 1998 Nov;83(11):3925-9. doi: 10.1210/jcem.83.11.5276.
4
Intracerebroventricular leptin increases lumbar and renal sympathetic nerve activity and blood pressure in normal rats.脑室内注射瘦素可增加正常大鼠的腰段及肾交感神经活动和血压。
Diabetes. 1997 Dec;46(12):2040-3. doi: 10.2337/diab.46.12.2040.
5
The metabolic significance of leptin in humans: gender-based differences in relationship to adiposity, insulin sensitivity, and energy expenditure.瘦素在人类中的代谢意义：与肥胖、胰岛素敏感性和能量消耗相关的性别差异。
J Clin Endocrinol Metab. 1997 Apr;82(4):1293-300. doi: 10.1210/jcem.82.4.3859.
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