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Leptin Receptors can be an Alternative Target for New Anti-hypertensive Drug Development.瘦素受体可成为新型抗高血压药物研发的替代靶点。
Indian J Endocrinol Metab. 2017 Nov-Dec;21(6):929-930. doi: 10.4103/ijem.IJEM_564_17.
2
Adipocytokine expression in placentas from pre-eclamptic and chronic hypertensive patients.子痫前期和慢性高血压患者胎盘组织中脂肪细胞因子的表达
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[Advances in the relationship between leptin and hypertensive-left ventricular hypertrophy].[瘦素与高血压性左心室肥厚关系的研究进展]
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The inhibitory effect of leptin on angiotensin II-induced vasoconstriction is blunted in spontaneously hypertensive rats.在自发性高血压大鼠中,瘦素对血管紧张素II诱导的血管收缩的抑制作用减弱。
J Hypertens. 2006 Aug;24(8):1589-97. doi: 10.1097/01.hjh.0000239295.17636.6e.
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Plasma leptin level is positively associated with blood pressure measures independent of gender and BMI.血浆瘦素水平与血压指标呈正相关,与性别和 BMI 无关。
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Transforming growth factor-beta1 levels in hypertensive patients: association with body mass index and leptin.高血压患者体内转化生长因子-β1水平:与体重指数和瘦素的关联
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本文引用的文献

1
Elevated plasma immunoreactive leptin levels preexist in healthy offspring of patients with essential hypertension.原发性高血压患者的健康后代中,血浆免疫反应性瘦素水平升高的情况在疾病发生前就已存在。
Am Heart J. 1999 Nov;138(5 Pt 1):922-5. doi: 10.1016/s0002-8703(99)70018-9.
2
Is there a role for the ob gene product leptin in essential hypertension?肥胖基因产物瘦素在原发性高血压中起作用吗?
Am J Hypertens. 1998 Nov;11(11 Pt 1):1305-11. doi: 10.1016/s0895-7061(98)00162-9.
3
Human adipose tissue expresses angiotensinogen and enzymes required for its conversion to angiotensin II.人体脂肪组织表达血管紧张素原及其转化为血管紧张素II所需的酶。
J Clin Endocrinol Metab. 1998 Nov;83(11):3925-9. doi: 10.1210/jcem.83.11.5276.
4
Intracerebroventricular leptin increases lumbar and renal sympathetic nerve activity and blood pressure in normal rats.脑室内注射瘦素可增加正常大鼠的腰段及肾交感神经活动和血压。
Diabetes. 1997 Dec;46(12):2040-3. doi: 10.2337/diab.46.12.2040.
5
The metabolic significance of leptin in humans: gender-based differences in relationship to adiposity, insulin sensitivity, and energy expenditure.瘦素在人类中的代谢意义:与肥胖、胰岛素敏感性和能量消耗相关的性别差异。
J Clin Endocrinol Metab. 1997 Apr;82(4):1293-300. doi: 10.1210/jcem.82.4.3859.

Leptin Receptors can be an Alternative Target for New Anti-hypertensive Drug Development.

作者信息

Ramkumar Mridula, Kanthlal S K

机构信息

QuintilesIMS, Bengaluru, Karnataka, India.

Department of Pharmacology, Amrita School of Pharmacy, Amrita Vishwa Vidyapeetham, AIMS Health Sciences Campus, Kochi, Kerala, India.

出版信息

Indian J Endocrinol Metab. 2017 Nov-Dec;21(6):929-930. doi: 10.4103/ijem.IJEM_564_17.

DOI:10.4103/ijem.IJEM_564_17
PMID:29285462
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5729687/
Abstract
摘要