Suter P M, Locher R, Häsler E, Vetter W
University Hospital, Department of Medicine, Medical Policlinic, Zürich, Switzerland.
Am J Hypertens. 1998 Nov;11(11 Pt 1):1305-11. doi: 10.1016/s0895-7061(98)00162-9.
In this study we wanted to evaluate the relationship between the ob gene product leptin and blood pressure, as well as plasma renin activity and plasma aldosterone levels. We studied 139 subjects with a mean+/-SD age of 50 +/-14 years and a body mass index of 26.5+/-5.3 kg/m2; 110 subjects had essential hypertension and 29 were healthy nonhypertensive controls. Blood pressure was measured in resting conditions in the morning and blood was drawn for the determination of the plasma renin activity, aldosterone, and leptin levels. The mean blood pressure of the population was 155/97 mm Hg. The relationship between these parameters was studied by univariate regression analysis according to gender and, whenever indicated, adjusted for age and body mass. The mean+/-SEM plasma leptin level in the whole population was 9.5+/-0.6 ng/mL (range, 1.1-43.3). Subjects with stage I hypertension had significantly higher plasma leptin levels than normotensive subjects. Systolic blood pressure correlated with the plasma leptin levels and the leptin levels adjusted for body weight in women (r = 0.422, P < .01) and nonhypertensive men (r = 0.644, P = .03) only. Plasma renin activity (r = 0.329, P = .03) and aldosterone levels (r = 0.342, P = .026) correlated with the leptin concentration. A significant relationship between the peripheral expression of the ob gene product leptin and systolic blood pressure was found in women and nonhypertensive men. In view of the multiple functions of leptin a causal relationship is postulated and potential mechanisms may involve modulatory effects of leptin on neuropeptide Y, angiotensinogen gene expression, the modulation of the autonomous nervous system, or effects on the pituitary adrenal axis. Direct relationships between both plasma renin activity and aldosterone levels and leptin support the potential importance of the relationship between leptin and blood pressure. Our observation may be of future importance for the understanding of the link between the increase in blood pressure and increasing body weight.
在本研究中，我们旨在评估肥胖基因产物瘦素与血压、血浆肾素活性及血浆醛固酮水平之间的关系。我们研究了139名受试者，其平均年龄±标准差为50±14岁，体重指数为26.5±5.3kg/m²；其中110名受试者患有原发性高血压，29名是健康的非高血压对照者。于早晨静息状态下测量血压，并采集血样以测定血浆肾素活性、醛固酮及瘦素水平。该人群的平均血压为155/97mmHg。根据性别通过单变量回归分析研究这些参数之间的关系，并在必要时对年龄和体重进行校正。整个人群的平均±标准误血浆瘦素水平为9.5±0.6ng/mL（范围为1.1 - 43.3）。I期高血压患者的血浆瘦素水平显著高于血压正常者。收缩压仅在女性（r = 0.422，P <.01）和非高血压男性（r = 0.644，P =.03）中与血浆瘦素水平及校正体重后的瘦素水平相关。血浆肾素活性（r = 0.329，P =.03）和醛固酮水平（r = 0.342，P =.026）与瘦素浓度相关。在女性和非高血压男性中发现肥胖基因产物瘦素的外周表达与收缩压之间存在显著关系。鉴于瘦素的多种功能，推测存在因果关系，潜在机制可能涉及瘦素对神经肽Y、血管紧张素原基因表达的调节作用、自主神经系统的调节或对垂体 - 肾上腺轴的影响。血浆肾素活性和醛固酮水平与瘦素之间的直接关系支持了瘦素与血压之间关系的潜在重要性。我们的观察结果可能对理解血压升高与体重增加之间的联系具有未来重要意义。
