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Telomeric zinc-finger associated protein (TZAP): a new player in telomere diseases?端粒锌指相关蛋白(TZAP):端粒疾病中的新角色?
Ann Transl Med. 2017 Dec;5(23):472. doi: 10.21037/atm.2017.09.37.
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Telomeric zinc-finger associated protein (TZAP) in cancer biology: friend or foe?癌症生物学中的端粒锌指相关蛋白(TZAP):是友还是敌?
Mol Biol Res Commun. 2021 Sep;10(3):121-129. doi: 10.22099/mbrc.2021.40106.1607.
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TZAP: A telomere-associated protein involved in telomere length control.TZAP:一种参与端粒长度调控的端粒相关蛋白。
Science. 2017 Feb 10;355(6325):638-641. doi: 10.1126/science.aah6752. Epub 2017 Jan 12.
4
Mass Spectrometry-Based Quantitative Proteomics Analysis for Better Understanding of Telomeric Zinc Finger-Associated Protein-Induced Pathogenesis in Cardiomyocytes.基于质谱的定量蛋白质组学分析有助于更好地理解端粒锌指相关蛋白诱导的心肌细胞发病机制。
Int Heart J. 2022;63(3):566-577. doi: 10.1536/ihj.21-354.
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TZAP Mutation Leads to Poor Prognosis of Patients with Breast Cancer .TZAP 突变导致乳腺癌患者预后不良。
Medicina (Kaunas). 2019 Nov 18;55(11):748. doi: 10.3390/medicina55110748.
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Clinicopathological Characteristics of TZAP Expression in Colorectal Cancers.结直肠癌中TZAP表达的临床病理特征
Onco Targets Ther. 2020 Dec 17;13:12933-12942. doi: 10.2147/OTT.S274394. eCollection 2020.
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TZAP plays an inhibitory role in the self-renewal of porcine mesenchymal stromal cells and is implicated the regulation of premature senescence via the p53 pathway.TZAP 在猪间充质基质细胞的自我更新中发挥抑制作用,并通过 p53 途径参与调节过早衰老。
J Transl Med. 2019 Mar 7;17(1):72. doi: 10.1186/s12967-019-1820-8.
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The 11th C2H2 zinc finger and an adjacent C-terminal arm are responsible for TZAP recognition of telomeric DNA.第11个C2H2锌指结构和相邻的C末端臂负责TZAP对端粒DNA的识别。
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Zinc finger protein overexpressed in colon carcinoma interacts with the telomeric protein hRap1.在结肠癌中过表达的锌指蛋白与端粒蛋白hRap1相互作用。
J Cell Biochem. 2005 Jul 1;95(4):763-8. doi: 10.1002/jcb.20487.
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Selection of zinc fingers that bind single-stranded telomeric DNA in the G-quadruplex conformation.选择能与处于G-四链体构象的单链端粒DNA结合的锌指蛋白。
Biochemistry. 2001 Jan 23;40(3):830-6. doi: 10.1021/bi001728v.

引用本文的文献

1
Telomeric zinc-finger associated protein (TZAP) in cancer biology: friend or foe?癌症生物学中的端粒锌指相关蛋白(TZAP):是友还是敌?
Mol Biol Res Commun. 2021 Sep;10(3):121-129. doi: 10.22099/mbrc.2021.40106.1607.
2
Positive correlation between TZAP and TERT in most cancers: a new player in cancer diseases.在大多数癌症中,TZAP与端粒酶逆转录酶(TERT)呈正相关:癌症疾病中的一个新角色。
Ann Transl Med. 2018 May;6(10):197. doi: 10.21037/atm.2018.03.14.

本文引用的文献

1
Telomere biology and telomerase mutations in cirrhotic patients with hepatocellular carcinoma.肝硬化合并肝细胞癌患者的端粒生物学与端粒酶突变
PLoS One. 2017 Aug 16;12(8):e0183287. doi: 10.1371/journal.pone.0183287. eCollection 2017.
2
Telomerase enzyme deficiency promotes metabolic dysfunction in murine hepatocytes upon dietary stress.端粒酶缺乏促进膳食应激下小鼠肝细胞的代谢功能障碍。
Liver Int. 2018 Jan;38(1):144-154. doi: 10.1111/liv.13529. Epub 2017 Aug 19.
3
Telomerase reverse transcriptase germline mutations and hepatocellular carcinoma in patients with nonalcoholic fatty liver disease.非酒精性脂肪性肝病患者的端粒酶逆转录酶种系突变与肝细胞癌
Cancer Med. 2017 Aug;6(8):1930-1940. doi: 10.1002/cam4.1078. Epub 2017 Jul 4.
4
ZBTB48 is both a vertebrate telomere-binding protein and a transcriptional activator.锌指和BTB结构域蛋白48(ZBTB48)既是一种脊椎动物端粒结合蛋白,也是一种转录激活因子。
EMBO Rep. 2017 Jun;18(6):929-946. doi: 10.15252/embr.201744095. Epub 2017 May 12.
5
TZAP-ing telomeres down to size.TZAP 技术可将端粒缩小至合适尺寸。
EMBO Rep. 2017 Jun;18(6):861-863. doi: 10.15252/embr.201744354. Epub 2017 May 12.
6
Phylointeractomics reconstructs functional evolution of protein binding.系统发生相互作用组学重建蛋白质结合的功能进化。
Nat Commun. 2017 Feb 8;8:14334. doi: 10.1038/ncomms14334.
7
TZAP: A telomere-associated protein involved in telomere length control.TZAP:一种参与端粒长度调控的端粒相关蛋白。
Science. 2017 Feb 10;355(6325):638-641. doi: 10.1126/science.aah6752. Epub 2017 Jan 12.
8
Telomeres, NAFLD and Chronic Liver Disease.端粒、非酒精性脂肪性肝病与慢性肝病
Int J Mol Sci. 2016 Mar 15;17(3):383. doi: 10.3390/ijms17030383.
9
Regulation of telomere length and homeostasis by telomerase enzyme processivity.端粒酶酶的进程性对端粒长度和稳定性的调节。
J Cell Sci. 2013 Jan 15;126(Pt 2):676-87. doi: 10.1242/jcs.119297. Epub 2012 Nov 23.
10
Mitochondria and cancer.线粒体与癌症。
Nat Rev Cancer. 2012 Oct;12(10):685-98. doi: 10.1038/nrc3365.

Telomeric zinc-finger associated protein (TZAP): a new player in telomere diseases?

作者信息

Donati Benedetta, Valenti Luca

机构信息

Laboratory of Translational Research, Azienda Unità Sanitaria Locale-IRRCS, Reggio Emilia, Italy.

Department of Pathophysiology and Transplantation, Internal Medicine and Metabolic Diseases, Fondazione IRCCS Ca' Granda Policlinico Hospital, Università degli Studi di Milano, Milano, Italy.

出版信息

Ann Transl Med. 2017 Dec;5(23):472. doi: 10.21037/atm.2017.09.37.

DOI:10.21037/atm.2017.09.37
PMID:29285505
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5733329/
Abstract
摘要