大鼠睡眠剥夺：III. 完全睡眠剥夺

Sleep deprivation in the rat: III. Total sleep deprivation.

作者信息

Everson C A, Bergmann B M, Rechtschaffen A

机构信息

Department of Psychiatry, University of Chicago, Illinois 60637.

出版信息

Sleep. 1989 Feb;12(1):13-21. doi: 10.1093/sleep/12.1.13.

DOI:10.1093/sleep/12.1.13

PMID:2928622

Abstract

Ten rats were subjected to total sleep deprivation (TSD) by the disk apparatus. All TSD rats died or were sacrificed when death seemed imminent within 11-32 days. No anatomical cause of death was identified. All TSD rats showed a debilitated appearance, lesions on their tails and paws, and weight loss in spite of increased food intake. Their yoked control (TSC) rats remained healthy. Since dehydration was ruled out and several measures indicated accelerated use rather than failure to absorb nutrients, the food-weight changes in TSD rats were attributed to increased energy expenditure (EE). The measurement of EE, based upon caloric value of food, weight, and wastes, indicated that all TSD rats increased EE, with mean levels reaching more than twice baseline values.

摘要

十只大鼠通过转盘装置接受完全睡眠剥夺（TSD）。所有接受TSD的大鼠在11至32天内死亡或在似乎即将死亡时被处死。未发现解剖学上的死因。所有接受TSD的大鼠尽管食物摄入量增加，但外观衰弱，尾巴和爪子有损伤，体重减轻。它们的配对对照（TSC）大鼠保持健康。由于排除了脱水因素，且多项测量表明能量消耗加速而非营养吸收失败，因此将接受TSD大鼠的食物-体重变化归因于能量消耗（EE）增加。基于食物热量值、体重和排泄物对EE进行测量，结果表明所有接受TSD的大鼠EE均增加，平均水平达到基线值的两倍以上。