Division of Orthopaedics, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Department of Pediatric Oncology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania.
Pediatr Blood Cancer. 2018 Apr;65(4). doi: 10.1002/pbc.26905. Epub 2017 Dec 29.
Total body irradiation (TBI) is commonly used in conditioning regimens for allogeneic hematopoietic stem cell transplantation (HSCT) to treat benign and malignant disease. Though life-saving, these therapies place patients at risk for important side effects, including musculoskeletal complications such as short stature, osteonecrosis, slipped capital femoral epiphysis, and the development of benign and malignant bone tumors. With an increasing number of HSCT survivors, there is a growing need for awareness of the musculoskeletal complications of HSCT and TBI.
全身放射治疗（TBI）常用于异基因造血干细胞移植（HSCT）的预处理方案中，以治疗良性和恶性疾病。尽管这些治疗方法可以挽救生命，但它们也使患者面临重要的副作用风险，包括肌肉骨骼并发症，如身材矮小、骨坏死、股骨头滑脱和良性及恶性骨肿瘤的发生。随着越来越多的 HSCT 幸存者，人们越来越需要意识到 HSCT 和 TBI 的肌肉骨骼并发症。
