Blum M, Schweitzer A
Clinique Mishmar Hayarden pour la Planification de la Famile, Kupar Holim du District Dan, Gyvatayim, Israël.
Rev Fr Gynecol Obstet. 1989 Jan;84(1):15-7.
One-hundred forty women (60 pregnant and 80 non-pregnant women) with a history of Candida albicans infection were examined one month before treatment and were reexamined one month after treatment. Administration of a single agent consisting of 2,300 mg tablets of GynoTragoven (isoconazole nitrate, Schering, AG) resulted in immediate clinical improvement. One month after treatment, the success rate was 85-100 p. cent for non-pregnant women, and 83-100 p. cent for pregnant women. No side-effects were observed following therapy. According to studies published, a high percentage of infections develop during pregnancy, especially during the second (35 p. cent) and third (31.5 p. cent) trimesters. Because of the high rate of infections during pregnancy, preventive therapy should be considered during the final weeks of pregnancy, to prevent intrauterine infection during parturition.
140名有白色念珠菌感染病史的女性（60名孕妇和80名非孕妇）在治疗前一个月接受检查，并在治疗后一个月再次接受检查。服用由2300毫克GynoTragoven（硝酸异康唑，先灵公司）片剂组成的单一药物后，临床症状立即得到改善。治疗一个月后，非孕妇的成功率为85%至100%，孕妇的成功率为83%至100%。治疗后未观察到副作用。根据已发表的研究，高比例的感染发生在孕期，尤其是在孕中期（35%）和孕晚期（31.5%）。由于孕期感染率高，应在妊娠最后几周考虑预防性治疗，以防止分娩时发生宫内感染。
