新生儿体重、胱抑素C与血清肌酐之间的关系。
The relationship between body weight, cystatin C and serum creatinine in neonates.
作者信息
Kandasamy Y, Rudd D, Smith R
机构信息
Department of Neonatology, The Townsville Hospital, QLD, Australia.
Mothers and Babies Research Centre, Hunter Medical Research Institute, John Hunter Hospital, The University of Newcastle, NSW, Australia.
出版信息
J Neonatal Perinatal Med. 2017;10(4):419-423. doi: 10.3233/NPM-171719.
BACKGROUND
Serum creatinine (SCr) measurement to determine glomerular filtration rate (GFR) in neonates has many pitfalls. Cystatin C (CysC) appears to be a more reliable biomarker.
METHODS
We investigated the effect of birth weight on SCr and CysC measurements in a cohort of 74 infants, consisting of both term and ex-premature infants at term postmenstrual age. SCr and Cys C measurements were carried out at the same time.
RESULTS
Eighty six infants were recruited into this study out of which complete data were available in 80 infants. The cohort consists of both term and premature infants at term PMA (31 terms and 49 preterms). The median SCr level was 17 [12-26] umol/L and mean CysC level was 1.64 [0.27] mg/L. SCr had a significant correlation with weight (r = 0.3; P = 0.011), whereas serum CysC had no correlation with the infant's weight (r = 0.01; P = 0.95). There were no statistically significant difference in SCr and CysC between male and female infants.
CONCLUSION
Unlike CysC, SCr had a significant correlation with birth weight. SCr based GFR measurement may cause a delay in diagnosis of acute kidney injury in smaller neonates.
背景
血清肌酐（SCr）测定用于确定新生儿的肾小球滤过率（GFR）存在诸多缺陷。胱抑素C（CysC）似乎是一种更可靠的生物标志物。
方法
我们在一个由74名婴儿组成的队列中研究了出生体重对SCr和CysC测量值的影响，该队列包括足月和过期早产婴儿，在月经龄足月时进行了SCr和Cys C测量。
结果
本研究共纳入86名婴儿，其中80名婴儿有完整数据。该队列包括足月和早产婴儿（31名足月婴儿和49名早产婴儿），SCr中位数水平为17[12 - 26]μmol/L，CysC平均水平为1.64[0.27]mg/L。SCr与体重显著相关（r = 0.3；P = 0.011），而血清CysC与婴儿体重无相关性（r = 0.01；P = 0.95）。男婴和女婴的SCr和CysC之间无统计学显著差异。
结论
与CysC不同，SCr与出生体重显著相关。基于SCr的GFR测量可能会延迟较小新生儿急性肾损伤的诊断。
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