Kaneko E, Ooi S, Ito G, Honda N
First Dept. of Medicine, School of Medicine, Hamamatsu University, Shizuoka, Japan.
Scand J Gastroenterol. 1989 Mar;24(2):165-70. doi: 10.3109/00365528909093032.
In a gastric mass survey with photofluorography performed on 10,605 male office workers over 40 years of age, 456 cases of duodenal ulcer (4.3%) were detected. These cases were scheduled to be followed up every 6 months with endoscopy and without any anti-ulcer drugs. Two hundred and seventy-six of the cases, including 169 cases with craters and 107 cases with scars, were followed up for 2 years. Forty-one of 169 craters (24.3%) had healed, and 21 of 107 scars (19.6%) had relapsed at 6 months. At 24 months 36 of 169 craters (21.3%) had healed, and 31 of 107 scars (29.0%) had relapsed. Sixty-four and a half per cent of the ulcers that showed crater at entry remained at the crater stage, and 62.6% of ulcer scars at entry remained healed at every endoscopy during the trial period. With regard to the cases' background, cigarette smoking adversely affected the natural history of the duodenal ulcer. However, years after onset, previous treatment, history of overt bleeding, and alcohol and coffee consumption did not affect the present ulcer activity.
在一项针对10605名40岁以上男性上班族进行的胃造影摄影胃部肿块调查中，检测出456例十二指肠溃疡（4.3%）。这些病例计划每6个月进行一次内镜检查随访，且不使用任何抗溃疡药物。其中276例患者，包括169例有溃疡龛影的患者和107例有瘢痕的患者，接受了为期2年的随访。在6个月时，169例溃疡龛影中有41例（24.3%）愈合，107例瘢痕中有21例（19.6%）复发。在24个月时，169例溃疡龛影中有36例（21.3%）愈合，107例瘢痕中有31例（29.0%）复发。入组时表现为溃疡龛影的溃疡中，64.5%在整个试验期间每次内镜检查时仍处于溃疡龛影阶段，入组时的溃疡瘢痕中，62.6%在每次内镜检查时均保持愈合状态。关于病例背景，吸烟对十二指肠溃疡的自然病程有不利影响。然而，发病数年、既往治疗情况、显性出血史以及酒精和咖啡摄入量对当前溃疡活动并无影响。
