Department of Biomedical Devices and Instrumentation, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, 2-3-10 Kanda-Surugadai, Chiyoda-ku, Tokyo 101-0062, Japan.
Graduate school of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, Japan.
Biosens Bioelectron. 2018 Apr 30;103:171-175. doi: 10.1016/j.bios.2017.12.016. Epub 2017 Dec 11.
Powering future generations of medical and health care devices mandates the transcutaneous transfer of energy or harvesting energy from the human body fluid. Glucose-driven bio fuel cells (bio-batteries) demonstrate promise as they produce electrical energy from glucose, which is a substrate presents in physiological fluids. Enzymatic biofuel cells can convert chemical energy into electrical energy using enzymes as catalysts. In this study, an air bio-battery was developed for healthcare and medical applications, consisting of a glucose-driven enzymatic biofuel cell using a direct gas-permeable membrane or a gas/liquid porous diaphragm. The power generation characteristics included a maximum current density of 285μA/cm and maximum power density of 70.7μW/cm in the presence of 5mmol/L of glucose in solution. In addition, high-performance, long-term-stabilized power generation was achieved using the gas/liquid porous diaphragm for the reactions between oxygen and enzyme. This system can be powered using 5mmol/L of glucose, the value of which is similar to that of the blood sugar range in humans.
为未来的医疗保健设备供电需要将能量经皮传递或从人体流体中获取能量。葡萄糖驱动的生物燃料电池（生物电池）具有广阔的应用前景，因为它们可以从葡萄糖中产生电能，而葡萄糖是生理液体中的一种基质。酶促生物燃料电池可以利用酶作为催化剂将化学能转化为电能。在这项研究中，开发了一种用于医疗保健和医疗应用的空气生物电池，它由一个使用直接透气膜或气/液多孔隔膜的葡萄糖驱动的酶促生物燃料电池组成。在溶液中存在 5mmol/L 葡萄糖的情况下，该发电的特征包括最大电流密度为 285μA/cm 和最大功率密度为 70.7μW/cm。此外，使用气/液多孔隔膜实现了高性能、长期稳定的酶与氧气之间的反应发电。该系统可以使用 5mmol/L 的葡萄糖供电，其值类似于人体血糖范围的值。
