Department of HIFU Treatment Room, The First Affiliated Hospital of Nanchang University, No. 17, Yongwai Road, Nanchang, 330006, China.
Department of Ultrasound, Jiangxi Provincial Maternal and Child Health Hospital, Nanchang, 330006, China.
Surg Endosc. 2018 Jul;32(7):3064-3069. doi: 10.1007/s00464-017-6017-8. Epub 2017 Dec 29.
The current treatment therapies for chyluria are often invasive and recurrent. Here, we investigated a novel noninvasive treatment of chyluria with high-intensity focused ultrasound (HIFU) and evaluated its clinical efficacy.
155 patients with chyluria were treated with HIFU ablation and followed up over a period of 15 years from May 2000 to December 2015. Routine examinations including urine color observation, color Doppler ultrasound examination, blood serum test of Cr, BUN, and albumin, and detection of urinary chyle were performed before and after the treatment, 1 week, 1 and 6 months post-treatment, and followed up via telephone and other forms. We lost contact with 54 patients during the course of the study.
In the 101 complete cases, the serum levels of Cr and BUN and the color Doppler ultrasound examination did not reveal significant differences before and after the treatment. However, there was a significant increase in the hemoglobin and albumin levels, as well as the body weight after the HIFU treatment. The other 54 patients also showed an improvement of the symptoms after the HIFU treatment before losing contact.
Our results suggest that the HIFU ablation therapy is a feasible, effective, and noninvasive method for the treatment of chyluria.
目前治疗乳糜尿的方法往往具有侵袭性且易复发。在这里，我们研究了高强度聚焦超声（HIFU）治疗乳糜尿的一种新的非侵入性方法，并评估了其临床疗效。
2000 年 5 月至 2015 年 12 月期间，我们对 155 例乳糜尿患者进行了 HIFU 消融治疗，并随访了 15 年。治疗前后、治疗后 1 周、1 个月和 6 个月，进行常规检查，包括尿色观察、彩色多普勒超声检查、血肌酐（Cr）、尿素氮（BUN）和白蛋白检测以及尿乳糜检测，在研究过程中我们与 54 例患者失去联系。
在 101 例完整病例中，Cr 和 BUN 血清水平以及彩色多普勒超声检查在治疗前后均无显著差异。然而，HIFU 治疗后血红蛋白和白蛋白水平以及体重显著增加。另外 54 例患者在失去联系前也表现出 HIFU 治疗后的症状改善。
我们的结果表明，HIFU 消融治疗是治疗乳糜尿的一种可行、有效、非侵入性的方法。
