Department of Oncology, CRUK/MRC Oxford Institute for Radiation Oncology, University of Oxford, UK.
Division of Radiation and Cancer Biology, Department of Radiation Oncology, Stanford University, CA, USA.
FEBS J. 2018 May;285(9):1563-1571. doi: 10.1111/febs.14377. Epub 2018 Jan 12.
The term hypoxia refers to any condition where insufficient oxygen is available and therefore encompasses a range of actual oxygen concentrations. The regions of tumours adjacent to necrotic areas are at almost anoxic levels and are known to be extremely therapy resistant (radiobiological hypoxia). The biological response to radiobiological hypoxia includes the rapid accumulation of replication stress and subsequent DNA damage response, including both ATR- and ATM-mediated signalling, despite the absence of detectable DNA damage. The causes and consequences of hypoxia-induced replication stress will be discussed.
缺氧是指氧气供应不足的任何情况，因此涵盖了一系列实际的氧气浓度。肿瘤与坏死区域相邻的区域几乎处于无氧状态，并且已知对治疗具有极强的抵抗力（放射生物学性缺氧）。放射生物学性缺氧的生物学反应包括快速积累复制应激，随后发生 DNA 损伤反应，包括 ATR 和 ATM 介导的信号传导，尽管没有检测到可检测的 DNA 损伤。将讨论缺氧诱导的复制应激的原因和后果。
