Immunology Department, Lyon-Sud Hospital, Hospices Civils de Lyon, Pierre-Bénite, France.
Endocrinology and Diabetes Department, Lyon-Sud Hospital, Hospices Civils de Lyon, Pierre-Bénite, France.
Clin Chim Acta. 2018 Mar;478:162-165. doi: 10.1016/j.cca.2017.12.043. Epub 2017 Dec 28.
Evaluate the added value of screening anti-ZnT8 antibodies (ZnT8A) in addition to the classical anti-GAD (GADA) and anti-IA-2 (IA-2A) antibodies for the diagnosis of type-1 diabetes (T1D) within a large cohort of both children and adults.
Retrospective 2-year study including 516 patients (215 children, 301 adults) who had blood tests at diabetes onset and/or for diabetes classification. ZnT8A, GADA, and IA-2A were analyzed in all samples.
Among those individuals included, 142 (28%) were ZnT8A-positive. A total of 228/516 suffered from T1D, of whom 110 (48%) were ZnT8A-positive and 166 (73%) GADA and/or IA-2A positive. When adding ZnT8A to GADA/IA-2A, 184 (81%) patients were positive for ≥1 Ab. Regarding the 122 patients at T1D onset, 75 (61%) were positive for ZnT8A and the proportion of patients with T1D with ≥1 Ab reached 89%. The highest prevalence of ZnT8A was observed in children aged 6-10years. Fourteen of the 124 patients positive for ZnT8A with a known clinical diagnosis suffered from a disease other than T1D.
ZnT8A should be included in routine evaluation at diabetes onset and is a valuable biological marker to classify newly-diagnosed diabetics. The predictive value in our high-risk subjects has to be confirmed.
在一个包括儿童和成人在内的大样本队列中，评估除了经典的抗谷氨酸脱羧酶（GADA）和抗胰岛细胞自身抗体（IA-2A）外，筛查抗锌转运体 8 抗体（ZnT8A）对 1 型糖尿病（T1D）的诊断价值。
这是一项回顾性的 2 年研究，共纳入 516 名（215 名儿童，301 名成人）在糖尿病发病时和/或为了糖尿病分类而进行血液检查的患者。所有样本均分析了 ZnT8A、GADA 和 IA-2A。
在纳入的这些个体中，有 142 人（28%）ZnT8A 阳性。516 名患者中共有 228 人患有 T1D，其中 110 人（48%）ZnT8A 阳性，166 人（73%）GADA 和/或 IA-2A 阳性。当将 ZnT8A 与 GADA/IA-2A 联合检测时，184 名（81%）患者至少有一种抗体阳性。对于 122 名发病时的 T1D 患者，有 75 名（61%）ZnT8A 阳性，且至少有一种 Ab 阳性的 T1D 患者比例达到 89%。ZnT8A 的最高阳性率见于 6-10 岁的儿童。在 124 名已知临床诊断为 ZnT8A 阳性的患者中，有 14 名患有 T1D 以外的疾病。
ZnT8A 应纳入糖尿病发病时的常规评估，是一种有价值的生物学标志物，可用于对新诊断的糖尿病患者进行分类。其在我们的高危人群中的预测价值有待证实。
