胰岛自身抗体对新诊断 1 型糖尿病患儿及其健康同胞的诊断能力。
Diagnostic Capabilities of Islet Autoantibodies in Children with New-Onset Type 1 Diabetes Mellitus and Healthy Siblings.
机构信息
Associate Professor, Department of Endocrinology and Internal Medicine; Privolzhsky Research Medical University, 10/1 Minin and Pozharsky Square, Nizhny Novgorod, 603005, Russia.
Professor, Head of the Department of Endocrinology and Internal Medicine; Privolzhsky Research Medical University, 10/1 Minin and Pozharsky Square, Nizhny Novgorod, 603005, Russia.
出版信息
Sovrem Tekhnologii Med. 2021;12(6):29-34. doi: 10.17691/stm2020.12.6.04. Epub 2020 Dec 28.
UNLABELLED
is to determine the diagnostic utility of several islet autoantibodies and their combinations in order to identify individuals susceptible to type 1 diabetes mellitus (T1DM) among healthy siblings in the pediatric population within the scope of the development of a screening program.
MATERIALS AND METHODS
A total of 424 children were evaluated, 260 children with new-onset T1DM and 164 healthy children with brothers and/or sisters with T1DM.Blood tests for a complex of autoantibodies to insulin (IAA), tyrosine phosphatase (IA-2A), zinc transporter 8 (ZnT8A), pancreatic β-cells (ICA), and glutamate decarboxylase (GADA) were conducted in all the subjects with the enzyme immunoassay method.
RESULTS
It was found that the diagnostic utility of individual autoantibodies is not equal and varies with age. The optimal age groups for the immunological control of the risks of developing type 1 diabetes in healthy siblings were determined. The highest risks were noted with the combination of GADA, ZnT8A, and IA-2A.
CONCLUSION
Islet autoantibodies may serve as prognostic markers of the risk of developing type 1 diabetes in healthy siblings.
目的
确定几种胰岛自身抗体及其组合在儿科人群中健康同胞中识别易患 1 型糖尿病（T1DM）个体的诊断效用，以便在筛查计划的范围内开发。
材料和方法
共评估了 424 名儿童，其中 260 名患有新发 T1DM，164 名健康儿童有患有 T1DM 的兄弟或姐妹。采用酶联免疫吸附法检测所有受试者的胰岛素（IAA）、酪氨酸磷酸酶（IA-2A）、锌转运体 8（ZnT8A）、胰岛β细胞（ICA）和谷氨酸脱羧酶（GADA）自身抗体复合物。
结果
发现个体自身抗体的诊断效用并不相等，并且随年龄而变化。确定了健康同胞发生 1 型糖尿病免疫风险的最佳年龄组。GADA、ZnT8A 和 IA-2A 的联合使用风险最高。
结论
胰岛自身抗体可作为健康同胞发生 1 型糖尿病风险的预后标志物。
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