Department of Neuroscience, Virginia Polytechnic Institute and State University, 1981 Kraft Drive, Blacksburg, VA 24060, USA.
Department of Neuroscience, Virginia Polytechnic Institute and State University, 1981 Kraft Drive, Blacksburg, VA 24060, USA; Translational Biology, Medicine, and Health, Virginia Polytechnic Institute and State University, 1 Riverside Circle, Roanoke, VA 24016, USA.
Front Neuroendocrinol. 2018 Jul;50:67-90. doi: 10.1016/j.yfrne.2017.12.004. Epub 2017 Dec 27.
Certain mood disorders and autoimmune diseases are predominately female diseases but we do not know why. Here, we explore the relationship between depression and the immune system from a sex-based perspective. This review characterizes sex differences in the immune system in health and disease. We explore the contribution of gonadal and stress hormones to immune function at the cellular and molecular level in the brain and body. We propose hormonal and genetic sex specific immune mechanisms that may contribute to the etiology of mood disorders.
某些心境障碍和自身免疫性疾病主要是女性疾病，但我们不知道原因。在这里，我们从基于性别的角度探讨了抑郁症与免疫系统之间的关系。本综述描述了免疫系统在健康和疾病中的性别差异。我们探讨了性腺和应激激素在大脑和身体的细胞和分子水平上对免疫功能的贡献。我们提出了可能导致心境障碍发病机制的激素和遗传性别特异性免疫机制。
