Department of Neurology, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605, Japan; Department of Neurology and Stroke Medicine, Yokohama City University Graduate School of Medicine, 3-9 Fukuura, Kanazawa-ku, Yokohama, Kanagawa 236-0004, Japan.
Department of Neurology, Teikyo University School of Medicine, 2-11-1 Kaga, Itabashi-ku, Tokyo 173-8605, Japan.
Clin Neurophysiol. 2018 Feb;129(2):345-348. doi: 10.1016/j.clinph.2017.11.007. Epub 2017 Nov 21.
The positive correlation between fasciculation potentials (FPs) and decremental responses in repetitive nerve stimulation test (RNS) in amyotrophic lateral sclerosis (ALS) patients has been described based on only one past study. We revisited this issue.
Subjects consisted of 30 prospectively-enrolled ALS patients on whom both needle EMG and RNS were conducted in the same trapezius muscle. Fasciculation potentials (FPs) were identified off-line from the restored 3-min signal. Firing rate of FPs (FR-FP) per minute was calculated from the total count of FPs of different origins. Correlations between FR-FP, decremental percentage (Decr%) and the amplitude of the initial compound muscle action potential (CMAPamp) in RNS were investigated.
There was no correlation between FR-FP and Decr% (r = 0.03) or between FR-FP and CMAPamp (r = 0.04). A significant negative correlation was observed between CMAPamp and Decr% (r = -0.56, P < .005).
FPs are not correlated with the decremental response in RNS.
The underlying mechanism for FPs and decremental responses in ALS must be different and unrelated to each other.
基于仅一项过去的研究，描述了肌萎缩侧索硬化症（ALS）患者的肌束震颤电位（FPs）与重复神经刺激测试（RNS）中的递减反应之间的正相关关系。我们重新探讨了这个问题。
研究对象包括 30 名前瞻性纳入的 ALS 患者，他们在同一斜方肌上同时进行了针式肌电图和 RNS。从恢复的 3 分钟信号中离线识别肌束震颤电位（FPs）。每分钟的 FPs 发放率（FR-FP）是根据不同起源的 FPs 的总数计算得出的。研究了 FR-FP 与递减百分比（Decr%）和 RNS 中初始复合肌肉动作电位（CMAPamp）振幅之间的相关性。
FR-FP 与 Decr%（r=0.03）或 FR-FP 与 CMAPamp（r=0.04）之间均无相关性。CMAPamp 与 Decr%之间存在显著负相关（r=-0.56，P<.005）。
FPs 与 RNS 中的递减反应不相关。
ALS 中 FPs 和递减反应的潜在机制必须不同且彼此无关。
