Department of Gastroenterology, Justus-Liebig-University, Giessen, Germany.
Matrix Biol. 2018 Aug;68-69:463-473. doi: 10.1016/j.matbio.2017.12.012. Epub 2017 Dec 28.
Liver fibrosis, a reversible wound-healing response to chronic cellular injury, reflects a balance between liver repair and progressive substitution of the liver parenchyma by scar tissue. Complex mechanisms that underlie liver fibrogenesis are summarized to provide the basis for generating targeted therapies to reverse fibrogenesis and improve the outcomes of patients with chronic liver disease. This minireview presents some pathophysiological aspects of liver fibrosis as a dynamic process and elucidates matrix metalloproteinases (MMPs) and their role within as well as beyond matrix degradation. Open questions remain, whether inhibition of fibrogenesis or induction of fibrolysis is the key mechanism to resolve fibrosis. And a point of principle might be whether regeneration of liver cirrhosis is possible. Will we ever cure fibrosis?
肝纤维化是一种对慢性细胞损伤的可逆转的伤口愈合反应，反映了肝脏修复和瘢痕组织对肝脏实质进行渐进性替代之间的平衡。总结了肝纤维化发生的复杂机制，为开发靶向治疗以逆转肝纤维化和改善慢性肝病患者的预后提供了依据。这篇综述介绍了肝纤维化作为一个动态过程的一些病理生理学方面，并阐明了基质金属蛋白酶（MMPs）及其在基质降解内外的作用。目前仍存在一些悬而未决的问题，例如抑制纤维化或诱导纤维溶解是否是解决纤维化的关键机制。一个原则性的问题可能是肝硬化的再生是否有可能。我们能治愈纤维化吗？
