Center of Excellence in Functional Materials at Biological Interfaces, Åbo Akademi University, Porthansgatan 3-5, 20500 Åbo, Finland; Laboratory of Physical Chemistry, Åbo Akademi University, Porthansgatan 3-5, 20500 Åbo, Finland.
Laboratory of Physical Chemistry, Åbo Akademi University, Porthansgatan 3-5, 20500 Åbo, Finland.
J Pharm Sci. 2018 May;107(5):1392-1397. doi: 10.1016/j.xphs.2017.12.025. Epub 2017 Dec 29.
The interaction between disulfiram (Antabus) and silica was studied experimentally by adsorption from apolar solvent onto highly porous silica material (Santa Barbara amorphous material-3) with large surface area. The adsorption isotherm was fitted to the Langmuir model by accounting 2 different affinities contributing to the overall behavior, which were attributed to 2 different types of silanol groups (i.e., geminal and vicinal) present on amorphous silica surfaces. This assumption was supported by theoretical calculations. In addition, the model could describe the adsorption of ibuprofen to the carrier material, indicating that the model bears big potential for describing the interactions between silica surfaces and drug molecules.
实验研究了戒酒硫（安塔布司）与二氧化硅之间的相互作用，方法是通过从非极性溶剂中吸附到具有大表面积的高多孔二氧化硅材料（圣巴巴拉无定形材料-3）上。通过考虑对整体行为有贡献的 2 种不同亲和力，将吸附等温线拟合到 Langmuir 模型中，这归因于无定形二氧化硅表面上存在的 2 种不同类型的硅醇基团（即偕二醇和邻二醇）。这一假设得到了理论计算的支持。此外，该模型可以描述布洛芬对载体材料的吸附，表明该模型在描述二氧化硅表面和药物分子之间的相互作用方面具有很大的潜力。
