Chemistry Department, Faculty of Science, Alexandria University, Egypt.
Chemistry Department, Faculty of Science, Damanhour University, Egypt.
Spectrochim Acta A Mol Biomol Spectrosc. 2018 Mar 15;193:458-466. doi: 10.1016/j.saa.2017.12.060. Epub 2017 Dec 24.
Synthesis, physicochemical characterization and thermal analysis of ceftazidime complexes with transition metals (Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II), Cd(II) and Hg(II)) were discussed. It's obtained that ceftazidime act as bidentate ligand. From magnetic measurement and spectral data, octahedral structures were proposed for all complexes except for cobalt, nickel and mercury had tetrahedral structural. Hyper chemistry program confirmed binding sites of ceftazidime. Ceftazidime complexes show higher activity than ceftazidime for some strains. From TG and DTA curves the thermal decomposition mechanisms of ceftazidime and their metal complexes were suggested. The thermal decomposition of the complexes ended with the formation of metal oxides as a final product except in case of Hg complex.
讨论了与过渡金属（Cr（III）、Mn（II）、Fe（III）、Co（II）、Ni（II）、Cu（II）、Zn（II）、Cd（II）和 Hg（II））的头孢他啶配合物的合成、物理化学特性和热分析。结果表明，头孢他啶作为双齿配体。根据磁性测量和光谱数据，除了钴、镍和汞外，所有配合物都提出了八面体结构，它们具有四面体结构。Hyper chemistry 程序证实了头孢他啶的结合位点。与头孢他啶相比，头孢他啶配合物对某些菌株的活性更高。从 TG 和 DTA 曲线中，提出了头孢他啶及其金属配合物的热分解机制。除了 Hg 配合物外，配合物的热分解最终以金属氧化物的形式形成最终产物。
