Pflugshaupt C
Ther Umsch. 1989 Feb;46(2):89-93.
With dermal preparations the therapeutic effect of the active ingredient is considerably influenced by factors such as the properties of the base and the type and conditions of the skin. In this respect, the correlation between the effect of the bases and the acuteness of the disease is the following: the more acute the disease, the more important the base and the less important the active ingredient. For dermal preparations there is consequently a therapeutic need for a differentiated spectrum of suitable bases. The choice of the appropriate vehicle plays a considerable role in the success of the treatment. The criteria for the selection of suitable vehicles are discussed on the basis of various examples.
对于皮肤制剂而言,活性成分的治疗效果会受到诸多因素的显著影响,比如基质的性质以及皮肤的类型和状况。在这方面,基质的效果与疾病的急性程度之间的关系如下:疾病越急性,基质就越重要,而活性成分则越不重要。因此,对于皮肤制剂来说,治疗上需要有一系列不同的合适基质。合适载体的选择在治疗成功与否方面起着相当重要的作用。基于各种实例讨论了选择合适载体的标准。